Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCAFXM)

Drug Name

ALX-101 Drug Info

Synonyms

Rovazolac; UNII-W51K389XIL; W51K389XIL; Rovazolac [INN]; GTPL9625; SCHEMBL15242823; ZUMNJDGBYXHASJ-UHFFFAOYSA-N; example 36 [WO2013130892]; HY-109073; CS-0033536; A-110; ethyl 2-[5-[4-(3-methylsulfonylphenyl)phenyl]-3-(trifluoromethyl)pyrazol-1-yl]acetate; ethyl 2-(5-(3'-(methylsulfonyl)biphenyl-4-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetate; ethyl 2-(5-(3'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetate; Ethyl 2-(5-(3'-(methylsulfonyl)-(1,1'-biphenyl)-4-yl)-3-(trifluoromethy

Indication

Disease Entry	ICD 11	Status	REF
Atopic dermatitis	EA80	Phase 2	[1]

Cross-matching ID

PubChem CID: 89792952
CAS Number: CAS 1454288-88-0
TTD Drug ID: DMCAFXM

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Oxysterols receptor LXR (NR1H)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
RGX-104	DM5AIKR	Non-small-cell lung cancer	2C25.Y	Phase 1/2	[2]
BMS-779788	DMKR8S1	Arteriosclerosis	BD40	Phase 1	[3]
CS-8080	DMRH740	Arteriosclerosis	BD40	Phase 1	[3]
BMS-852927	DMZS1D2	Arteriosclerosis	BD40	Phase 1	[3]
XL-041	DMYSQHT	Arteriosclerosis	BD40	Phase 1	[4]
XL652/XL014	DM89NML	Cardiovascular disease	BA00-BE2Z	Phase 1	[5]
LXR 623	DM3OP41	Arteriosclerosis	BD40	Phase 1	[3]
T0901317	DMZQVDI	Discovery agent	N.A.	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Oxysterols receptor LXR (NR1H)	TTM1EQF	NOUNIPROTAC	Agonist	[1]

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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	Liver X receptors in lipid metabolism: opportunities for drug discovery. Nat Rev Drug Discov. 2014 Jun;13(6):433-44.
4	Emerging small molecule drugs. Handb Exp Pharmacol. 2015;224:617-30.
5	Clinical pipeline report, company report or official report of Exelixis (2011).
6	The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse. J Lipid Res. 2003 Nov;44(11):2039-48.