Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCDWSG)

Drug Name

ISIS 298711 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting HIF1-alpha messenger RNA (HIF1A mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PT2385	DMCSN69	Recurrent glioblastoma	2A00.00	Phase 2	[2]
(5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol	DM15P2G	Discovery agent	N.A.	Investigative	[3]
ISIS 298697	DM0WH1L	Discovery agent	N.A.	Investigative	[1]
ISIS 298744	DM8VMQ4	Discovery agent	N.A.	Investigative	[1]
ISIS 298746	DMHOJ0Z	Discovery agent	N.A.	Investigative	[1]
ISIS 298745	DM9YMPI	Discovery agent	N.A.	Investigative	[1]
ISIS 298743	DMD3NSQ	Discovery agent	N.A.	Investigative	[1]
ISIS 298702	DM4L7NE	Discovery agent	N.A.	Investigative	[1]
ISIS 298700	DM3DE98	Discovery agent	N.A.	Investigative	[1]
ISIS 175510	DMPAXR4	Discovery agent	N.A.	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
HIF1-alpha messenger RNA (HIF1A mRNA)	TTSN6QU	HIF1A_HUMAN	Not Available	[1]

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References

1	US patent application no. 7,217,572, Modulation of HIF1.alpha. and HIF2.alpha. expression.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	Synthesis of (aryloxyacetylamino)-isonicotinic/nicotinic acid analogues as potent hypoxia-inducible factor (HIF)-1alpha inhibitors. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6305-10.