General Information of Drug (ID: DMCE3NA)

Drug Name
CEPHARANTINE Drug Info
Synonyms cepharantine; CHEMBL500862; BDBM50242977
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
7098680
TTD Drug ID
DMCE3NA

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [2]
Bivalirudin DMECRX1 Thrombocytopenia 3B64 Approved [3]
Flavin-Adenine Dinucleotide DM5S4GK Discovery agent N.A. Investigative [4]
CONESSINE DM4VYP0 Discovery agent N.A. Investigative [1]
Maleic Acid DM4L0R7 Discovery agent N.A. Investigative [5]
1-(2'-chlorophenyl)penta-1,4-dien-3-one DMKTZSY Discovery agent N.A. Investigative [6]
Trypanothione DMDUGQ1 Discovery agent N.A. Investigative [4]
N-(5-chloro-2-(phenylthio)phenyl)butyramide DMHZ256 Discovery agent N.A. Investigative [7]
N1,N2-bis(dihydrocaffeoyl)spermine DMSDVGQ Discovery agent N.A. Investigative [1]
⏷ Show the Full List of 9 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Trypanosoma Trypanothione reductase (Trypano TPR) TTRTKPV TYTR_TRYBB Inhibitor [1]

References

1 The use of natural product scaffolds as leads in the search for trypanothione reductase inhibitors. Bioorg Med Chem. 2008 Jul 15;16(14):6689-95.
2 Opportunities and challenges in antiparasitic drug discovery. Nat Rev Drug Discov. 2005 Sep;4(9):727-40.
3 8-Methoxy-naphtho[2,3-b]thiophen-4,9-quinone, a non-competitive inhibitor of trypanothione reductase. Mem Inst Oswaldo Cruz. 2003 Jun;98(4):565-8.
4 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
5 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
6 Irreversible inactivation of trypanothione reductase by unsaturated Mannich bases: a divinyl ketone as key intermediate. J Med Chem. 2005 Nov 17;48(23):7400-10.
7 Antitrypanosomal, antileishmanial, and antimalarial activities of quaternary arylalkylammonium 2-amino-4-chlorophenyl phenyl sulfides, a new class ... J Med Chem. 2005 Dec 15;48(25):8087-97.