Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCFGP3)

Drug Name

LKA651 Drug Info

Synonyms

45605

Indication

Disease Entry	ICD 11	Status	REF
Diabetic macular edema	9B71.02	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Erythropoietin (EPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MK-2578	DM1M57I	Anemia	3A00-3A9Z	Phase 2	[3]
Erythropoietin-transfected autologous cell therapy	DMNZ6VA	Anemia	3A00-3A9Z	Phase 1/2	[4]
Long-acting erythropoietin conjugate	DM9OA35	Anemia	3A00-3A9Z	Phase 1	[5]
GC-1113	DMK96CE	Anemia	3A00-3A9Z	Phase 1	[6]
FC EPO	DMEX12T	Anemia	3A00-3A9Z	Discontinued in Phase 1	[7]
GLY-515n	DM0IKB4	Cerebrovascular ischaemia	8B1Z	Terminated	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	ClinicalTrials.gov (NCT03927690) Multiple Dose Safety and Efficacy of LKA651 in Patients With Diabetic Macular Edema. U.S. National Institutes of Health.
2	Clinical pipeline report, company report or official report of Novartis.
3	Merck ditches biogeneric. Nat Biotechnol. 2010 Jul;28(7):636.
4	Mesenchymal stromal cells engineered to express erythropoietin induce anti-erythropoietin antibodies and anemia in allorecipients. Mol Ther. 2009 Feb;17(2):369-72.
5	Company report (Pharmexcil)
6	A long-acting erythropoietin fused with noncytolytic human Fc for the treatment of anemia. Arch Pharm Res. 2012 May;35(5):757-9.
7	Detection of EPO-Fc fusion protein in human blood: screening and confirmation protocols for sports drug testing. Drug Test Anal. 2012 Nov;4(11):818-29.
8	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027536)