Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCJMOS)

Drug Name

ALN-PCS Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Hypercholesterolaemia	5C80.0	Preclinical	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Preclinical Drug(s)

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Drug(s) Targeting PCSK9 messenger RNA (PCSK9 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Inclisiran	DMP3YTE	Familial hypercholesterolemia	5C80.00	Approved	[2]
MPSK3169A	DMMRYEK	Cardiovascular disease	BA00-BE2Z	Phase 2	[3]
AZD8233	DMBT2D2	Cardiovascular disease	BA00-BE2Z	Phase 2	[4]
BMS-PCSK9	DMRCMEK	Coronary artery disease	BA80	Preclinical	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	Clinical pipeline report, company report or official report of Alnylam Pharmaceuticals, Inc (2011).
2	FDA Approved Drug Products from FDA Official Website. 2021. Application Number: 214012.
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2388).
4	AZD8233 antisense oligonucleotide targeting PCSK9 does not prolong QT interval. Br J Clin Pharmacol. 2022 Nov;88(11):4839-4844.
5	Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2011).