Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCPM92)

Drug Name

CAR-T cells targeting CLL1 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
leukaemia	2A60-2B33	Phase 1/2	[1]
Lymphoma	2A80-2A86	Phase 1/2	[1]
Multiple myeloma	2A83	Phase 1/2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Preclinical Drug(s)

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Drug(s) Targeting Myeloid inhibitory C-type lectin-like receptor (CD371)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CD123/CLL1 CAR-T Cells	DM45Z3P	Acute myeloid leukaemia	2A60	Phase 2/3	[2]
CLL1 CAR-T Cell	DMUOMBZ	Acute myeloid leukaemia	2A60	Phase 2/3	[2]
CLL1-specific gene-engineered T cells	DMCT917	Acute myeloid leukaemia	2A60	Phase 1/2	[3]
Tepoditamab	DMC84Y9	Acute myelogenous leukaemia	2A41	Phase 1	[4]
CLL1-CD33 cCART cell therapy	DM5EM04	Acute myeloid leukaemia	2A60	Phase 1	[5]
CLT030	DM674MP	Acute myeloid leukaemia	2A60	Phase 1	[6]
KITE-222	DMPF49Z	Acute myeloid leukaemia	2A60	Phase 1	[7]
UCART-CLL1	DMT06MI	Multiple myeloma	2A83	Preclinical	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Myeloid inhibitory C-type lectin-like receptor (CD371)	TT70N8V	CL12A_HUMAN	CAR-T-Cell-Therapy	[1]

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References

1	ClinicalTrials.gov (NCT03312205) CAR-T Cells for Relapsed or Refractory Haematopoietic and Lymphoid Malignancies
2	ClinicalTrials.gov (NCT03631576) CD123/CLL1 CAR-T Cells for R/R AML
3	ClinicalTrials.gov (NCT03222674) Multi-CAR T Cell Therapy for Acute Myeloid Leukemia
4	MCLA-117, a CLEC12AxCD3 bispecific antibody targeting a leukaemic stem cell antigen, induces T cell-mediated AML blast lysis. Expert Opin Biol Ther. 2019 Jul;19(7):721-733.
5	Clinical pipeline report, company report or official report of iCell Gene Therapeutics.
6	Clinical pipeline report, company report or official report of Cellerant Therapeutics.
7	Clinical pipeline report, company report or official report of Gilead
8	Off-the-shelf' allogeneic CAR T cells: development and challenges. Nat Rev Drug Discov. 2020 Mar;19(3):185-199.