Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCRLQZ)

Drug Name

ARQ 621 Drug Info

Synonyms

ARQ 621; 1095253-39-6; ARQ-621; UNII-UU55190C8S; ARQ621; UU55190C8S; (R)-N-(3-AMINOPROPYL)-3-CHLORO-N-(1-(7-CHLORO-4-OXO-3-(PHENYLAMINO)-3,4-DIHYDROQUINAZOLIN-2-YL)BUT-3-YN-1-YL)-2-FLUOROBENZAMIDE; Benzamide, N-(3-aminopropyl)-3-chloro-N-[(1R)-1-[7-chloro-3,4-dihydro-4-oxo-3-(phenylamino)-2-quinazolinyl]-3-butyn-1-yl]-2-fluoro-; SCHEMBL361201; C28H24Cl2FN5O2; DTXSID80148974; EX-A857; UPJSUQWHUVLLNW-XMMPIXPASA-N; MolPort-035-789-699; BCP28395; 2122AH; ZINC68203755; s7355; AKOS032945139; SB19448; NCGC00386362-01; KB-74734

Indication

Disease Entry	ICD 11	Status	REF
Haematological malignancy	2B33.Y	Phase 1	[1]

Cross-matching ID

PubChem CID: 25110841
CAS Number: CAS 1095253-39-6
TTD Drug ID: DMCRLQZ

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Kinesin-like protein KIF11 (KIF11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AZD-4877	DMFVL5J	Acute myeloid leukaemia	2A60	Phase 2	[2]
ARRY-520	DMTOI7S	Multiple myeloma	2A83	Phase 2	[3]
Ispinesib	DMP2BWX	Head and neck cancer	2D42	Phase 2	[4]
SB-743921	DM6XJ9S	Solid tumour/cancer	2A00-2F9Z	Phase 2	[5]
LY2523355	DMCV602	Acute myeloid leukaemia	2A60	Phase 2	[2]
4SC-205	DMG75P3	Lymphoma	2A80-2A86	Phase 1	[6]
MK-0731	DM2TAUR	Solid tumour/cancer	2A00-2F9Z	Phase 1	[2]
Monastrol	DMLSEJN	Discovery agent	N.A.	Investigative	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Kinesin-like protein KIF11 (KIF11)	TTTRP0H	KIF11_HUMAN	Modulator	[2]

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References

1	ClinicalTrials.gov (NCT00825487) Dose Escalation Study of ARQ 621 in Adult Patients With Metastatic Solid Tumors and Hematologic Malignancies. U.S. National Institutes of Health.
2	Kinesins and cancer. Nat Rev Cancer. 2012 Jul 24;12(8):527-39.
3	Inhibition of KSP by ARRY-520 induces cell cycle block and cell death via the mitochondrial pathway in AML cells. Leukemia. 2009 Oct;23(10):1755-62.
4	Initial testing (stage 1) of the kinesin spindle protein inhibitor ispinesib by the pediatric preclinical testing program. Pediatr Blood Cancer. 2009 Dec 15;53(7):1255-63.
5	Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2009 Jan-Feb;31(1):47-57.
6	2011 Pipeline of 4SC AG.
7	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.