Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCW5A9)

Drug Name
(R,)-2-(2-naphthamido)-5-phenylpent-4-enoic acid Drug Info
Synonyms CHEMBL1090714; (2R,4E)-2-[(naphthalen-2-ylcarbonyl)amino]-5-phenylpent-4-enoic acid; (R,)-2-(2-naphthamido)-5-phenylpent-4-enoic acid; SCHEMBL16550527; SCHEMBL16550525; BDBM50314705
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
45100499
TTD Drug ID
DMCW5A9

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Rotamase Pin1 (PIN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Avastin+/-Tarceva DMA86FL Non-small-cell lung cancer 2C25.Y Phase 3 [2]
Beta-(2-Naphthyl)-Alanine DMP21ZO Discovery agent N.A. Investigative [3]
(R)-2-(2-naphthamido)-3-p-tolylpropanoic acid DMXGCYZ Discovery agent N.A. Investigative [1]
3,6,9,12,15,18-HEXAOXAICOSANE DMY26JI Discovery agent N.A. Investigative [3]
(R)-3-(2-naphthamido)-4-m-tolylbutanoic acid DM5TH2W Discovery agent N.A. Investigative [1]
(R)-2-(2-naphthamido)-3-m-tolylpropanoic acid DMVEMNA Discovery agent N.A. Investigative [1]
(R)-2-(2-naphthamido)-5-phenylpent-4-ynoic acid DM9WL6O Discovery agent N.A. Investigative [1]
Ac-Phe-D-Thr(PO3H2)-Pip-Nal-Gln-NH2 DM6ONY7 Discovery agent N.A. Investigative [4]
Ac-Phe-Thr(PO3H2)-Pip-Nal-Gln-NH2 DMSWTPX Discovery agent N.A. Investigative [4]
Ac-Bth-Thr(PO3H2)-Pip-Nal-Gln-NH2 DMSE29N Discovery agent N.A. Investigative [4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Rotamase Pin1 (PIN1) TTJNTSI PIN1_HUMAN Inhibitor [1]

References

1 Structure-based design of novel human Pin1 inhibitors (II). Bioorg Med Chem Lett. 2010 Apr 1;20(7):2210-4.
2 Overexpression of PIN1 Enhances Cancer Growth and Aggressiveness with Cyclin D1 Induction in EBV-Associated Nasopharyngeal Carcinoma.PLoS One. 2016 Jun 3;11(6):e0156833.
3 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
4 Nanomolar inhibitors of the peptidyl prolyl cis/trans isomerase Pin1 from combinatorial peptide libraries. J Med Chem. 2006 Apr 6;49(7):2147-50.