Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCXN80)

• Drug Name: Tozorakimab Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Acute respiratory failure	CB41.0	Phase 3	[1]
Chronic obstructive pulmonary disease	CA22	Phase 3	[2]

• Cross-matching ID: TTD Drug ID: DMCXN80

Molecule-Related Drug Atlas

Drug(s) Targeting Interleukin-33 (IL33)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SAR440340	DMKYXSS	Chronic obstructive pulmonary disease	CA22	Phase 3	[4]
Itepekimab	DMR8NDD	Chronic obstructive pulmonary disease	CA22	Phase 3	[4]
MEDI3506	DMDI7SA	Chronic obstructive pulmonary disease	CA22	Phase 3	[2]
AMG 282	DM92YWD	Asthma	CA23	Phase 1	[5]
PF-07264660	DM0GI2H	Atopic dermatitis	EA80	Phase 1	[6]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Interleukin-33 (IL33)	TT5MD4P	IL33_HUMAN	Inhibitor	[3]

References

• [1] ClinicalTrials.gov (NCT05624450) A Phase III, Multicentre, Randomised, Double-blind, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Tozorakimab (MEDI3506) in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen. U.S.National Institutes of Health.
• [2] ClinicalTrials.gov (NCT05742802) A Phase III, Multicentre, Randomised, Double-blind, Chronic-dosing, Parallel-group, Placebo-controlled Extension Study to Evaluate the Long-term Efficacy and Safety of Tozorakimab (MEDI3506) in Participants With Chronic Obstructive Pulmonary Disease (COPD) With a History of Exacerbations. U.S.National Institutes of Health.
• [3] ACCORD: A Multicentre, Seamless, Phase 2 Adaptive Randomisation Platform Study to Assess the Efficacy and Safety of Multiple Candidate Agents for the Treatment of COVID-19 in Hospitalised Patients: A structured summary of a study protocol for a randomised controlled trial. Trials. 2020 Jul 31;21(1):691.
• [4] Efficacy and Safety of Itepekimab in Patients with Moderate-to-Severe Asthma. N Engl J Med. 2021 Oct 28;385(18):1656-1668.
• [5] Clinical pipeline report, company report or official report of Amgen.
• [6] Clinical pipeline report, company report or official report of Pfizer