General Information of Drug (ID: DMD5F6Z)

Drug Name
N-[4'-(ethylsulfonyl)-3-fluoro-4-biphenylyl]urea Drug Info
Synonyms CHEMBL244512; BDBM50220161
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
23626454
TTD Drug ID
DMD5F6Z

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
ALN-VSP DM89DHO Liver cancer 2C12 Phase 1 [2]
EMD-534085 DMQ6YAZ Haematological malignancy 2B33.Y Phase 1 [3]
N-[4'-(trifluoromethyl)-4-biphenylyl]thiourea DMPVKWG Discovery agent N.A. Investigative [1]
N-[3'-(trifluoromethyl)-4-biphenylyl]urea DM7OA4R Discovery agent N.A. Investigative [1]
4'-(trifluoromethyl)-4-biphenylsulfonamide DMLP67R Discovery agent N.A. Investigative [1]
N-(4'-chloro-4-biphenylyl)methanesulfonamide DM0ARP8 Discovery agent N.A. Investigative [1]
ISIS 183881 DMOU9EP Discovery agent N.A. Investigative [4]
ISIS 183911 DMTB350 Discovery agent N.A. Investigative [5]
4'-(trifluoromethyl)-4-biphenylyl carbamate DMT3BX9 Discovery agent N.A. Investigative [1]
ISIS 183910 DMMQ2L7 Discovery agent N.A. Investigative [5]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Kinesin spindle messenger RNA (KIF11 mRNA) TTBGTCW KIF11_HUMAN Inhibitor [1]

References

1 Novel ATP-competitive kinesin spindle protein inhibitors. J Med Chem. 2007 Oct 4;50(20):4939-52.
2 Clinical pipeline report, company report or official report of Alnylam Pharmaceuticals, Inc (2011).
3 The discovery and optimization of hexahydro-2H-pyrano[3,2-c]quinolines (HHPQs) as potent and selective inhibitors of the mitotic kinesin-5. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1491-5.
4 US patent application no. 7,407,943, Antisense modulation of apolipoprotein B expression.
5 US patent application no. 7,163,927, Antisense modulation of kinesin-like 1 expression.