Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMD5WK4)

Drug Name

Gpi-1046 Drug Info

Synonyms

186452-09-5; gpi-1046; (S)-3-(Pyridin-3-yl)propyl 1-(3,3-dimethyl-2-oxopentanoyl)pyrrolidine-2-carboxylate; CHEMBL6367; L-Proline, 1-(3,3-dimethyl-1,2-dioxopentyl)-, 3-(3-pyridinyl)propyl ester; (2S)-[3-PYRIDYL-1-PROPYL]-1-[3,3-DIMETHYL-1,2-DIOXOPENTYL]-2-PYRROLIDINECARBOXYLATE; 3-pyridin-3-ylpropyl (2S)-1-(3,3-dimethyl-2-oxopentanoyl)pyrrolidine-2-carboxylate; 3-(pyridin-3-yl)propyl (2S)-1-(3,3-dimethyl-2-oxopentanoyl)pyrrolidine-2-carboxylate; GPI; AC1L9I3R; SCHEMBL4766380; BDBM23334; CTK0I3903; DTXSID00332191

Indication

Disease Entry	ICD 11	Status	REF
Parkinson disease	8A00.0	Terminated	[1]

Cross-matching ID

PubChem CID: 445501
CAS Number: CAS 186452-09-5
TTD Drug ID: DMD5WK4

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting FK506-binding protein 1A (FKBP1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GPI-1485	DM64ZYM	Parkinson disease	8A00.0	Phase 2	[3]
SDZ-281-240	DMPZ67G	Pruritus	EC90	Phase 2	[4]
AP1903	DM2LU8M	Transplant rejection	NE84	Phase 1/2	[5]
MYRISTIC ACID	DMYX0BL	Discovery agent	N.A.	Investigative	[2]
Heptyl-Beta-D-Glucopyranoside	DMPQBN0	Discovery agent	N.A.	Investigative	[6]
4-Hydroxy-2-Butanone	DM7BQ65	Discovery agent	N.A.	Investigative	[7]
L-709,587	DM9KCYQ	Discovery agent	N.A.	Investigative	[7]
Methyl Methylsulfinylmethyl Sulfide	DMOCXLW	Discovery agent	N.A.	Investigative	[7]
Rapamycin Immunosuppressant Drug	DM678IB	Discovery agent	N.A.	Investigative	[7]
FKB-001	DM9K834	Discovery agent	N.A.	Investigative	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
FK506-binding protein 1A (FKBP1A)	TTMW94E	FKB1A_HUMAN	Inhibitor	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008349)
2	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
3	Drugs used to treat Parkinson's disease, present status and future directions. CNS Neurol Disord Drug Targets. 2008 Oct;7(4):321-42.
4	Clearing of psoriasis by a novel immunosuppressive macrolide. J Invest Dermatol. 1996 Apr;106(4):701-10.
5	Using gene transfer to circumvent off-target effects. Gene Ther. 2008 May;15(10):759-64.
6	DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
7	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.