Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMD6H8B)

• Drug Name: GMZ-2 Drug Info
• Synonyms: Adjuvanted PfGLURP + PfMSP3 vaccine (malaria), AMANET; GLURP-MSP3 bivalent vaccine (malaria), EMVI; Malaria vaccine (PfGLURP + PfMSP3 + aluminium hydroxide adjuvant), EMVI

Indication

Disease Entry	ICD 11	Status	REF
Malaria	1F40-1F45	Phase 1	[1]

• Cross-matching ID: TTD Drug ID: DMD6H8B

Molecule-Related Drug Atlas

Drug(s) Targeting Cell mediated immunity response (CMIR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quattvaxem	DMGAZHU	Bordetella pertussis infection	1C12.0	Approved	[3]
H1N1 pandemic influenza A vaccine	DMFUAXT	Influenza virus infection	1E30-1E32	Approved	[4]
H5N1 influenza vaccine	DMMHYLB	Human immunodeficiency virus infection	1C62	Approved	[5]
Live attenuated influenza vaccine	DMX9PIA	Influenza virus infection	1E30-1E32	Approved	[6]
HEV-239	DMGUC9T	Hepatitis E virus infection	1E50.4	Approved	[7]
Polyoxidonium	DMJAOT1	Infectious disease	1A00-CA43.1	Approved	[8]
GSK2592984A	DM8QB0T	Influenza virus infection	1E30-1E32	Approved	[9]
Focetria A(H1N1)	DM2PSBE	Influenza virus infection	1E30-1E32	Approved	[10]
Fendrix	DM0LRU9	Hepatitis B virus infection	1E51.0	Approved	[11]
Arepanrix	DMVMY7K	Influenza virus infection	1E30-1E32	Approved	[12]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cell mediated immunity response (CMIR)	TT3J5ZI	NOUNIPROTAC	Not Available	[2]

References

• [1] ClinicalTrials.gov (NCT00424944) Safety of Recombinant Hybrid GMZ 2 [GLURP + MSP 3] Blood Stage Malaria Vaccine. U.S. National Institutes of Health.
• [2] Immunogenicity of a virosomally-formulated Plasmodium falciparum GLURP-MSP3 chimeric protein-based malaria vaccine candidate in comparison to adjuvanted formulations. Malar J. 2011; 10: 359.
• [3] Double-blind study comparing the immunogenicity of a licensed DTwPHib-CRM197 conjugate vaccine (Quattvaxem) with three investigational, liquid formulations using lower doses of Hib-CRM197 conjugate. Vaccine. 2005 Feb 25;23(14):1715-9.
• [4] How Influenza (Flu) Vaccines Are Made. FLU.gov. 2014.
• [5] Comparative clinical trial of vaccines against avian influenza. Zh Mikrobiol Epidemiol Immunobiol. 2007 May-Jun;(3):10-6.
• [6] Flu myths: dispelling the myths associated with live attenuated influenza vaccine. Mayo Clin Proc. 2008 Jan;83(1):77-84.
• [7] The development of a recombinant hepatitis E vaccine HEV 239. Hum Vaccin Immunother. 2015;11(4):908-14.
• [8] Effect of polyoxidonium on the phagocytic activity of human peripheral blood leukocytes. Russ J Immunol. 2003 Apr;8(1):53-60.
• [9] Anti-influenza agents from Traditional Chinese Medicine. Nat Prod Rep. 2010 Jan;27(12):1758-80.
• [10] Influenza A/H1N1 MF59 adjuvanted vaccine in pregnant women and adverse perinatal outcomes: multicentre study. BMJ. 2013 Feb 4;346:f393.
• [11] Revaccination with Fendrix or HBVaxPro results in better response rates than does revaccination with three doses of Engerix-B in previous non-responders. Vaccine. 2012 Nov 6;30(48):6734-7.
• [12] Comparison of Pandemrix and Arepanrix, two pH1N1 AS03-adjuvanted vaccines differentially associated with narcolepsy development. Brain Behav Immun. 2015 Jul;47:44-57.