Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMD9LWN)

Drug Name

Donidalorsen Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Hereditary angioedema	4A00.14	Phase 3	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Plasma kallikrein messenger RNA (KLKB1 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ISIS-PKK	DMKWBJR	Amyloid cardiomyopathy	5D00.20	Phase 3	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Plasma kallikrein messenger RNA (KLKB1 mRNA)	TTN0PCX	KLKB1_HUMAN	Not Available	[2]

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References

1	ClinicalTrials.gov (NCT05392114) An Open-Label, Long Term Safety and Efficacy Study of Donidalorsen in the Prophylactic Treatment of Hereditary Angioedema (HAE). U.S.National Institutes of Health.
2	Clinical pipeline report, company report or official report of Ionis
3	Clinical pipeline report, company report or official report of ISIS Pharmaceuticals.