Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDBZGP)

Drug Name

PNRI-299 Drug Info

Synonyms

PNRI-299; 550368-41-7; UNII-2WW6I6D1Z1; 2WW6I6D1Z1; PNRI299; ZINC1489322; BCP16043; AKOS030526844; CS-3985; HY-15131; 1H-(1,2,4)Triazolo(1,2-a)pyridazine-5-carboxamide, 2-(3-cyanophenyl)-2,3,7,8-tetrahydro-1,3,7-trioxo-N-(phenylmethyl)-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 10318848
CAS Number: CAS 550368-41-7
TTD Drug ID: DMDBZGP

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Discontinued Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Transcription factor AP-1 (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
T-5224	DMD3CUJ	Rheumatoid arthritis	FA20	Discontinued in Phase 2	[2]
TWS-119	DMS29M4	Discovery agent	N.A.	Investigative	[3]
TAM-67	DM26SE7	Discovery agent	N.A.	Investigative	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Transcription factor AP-1 (JUN)	TTN3GBV	JUN_HUMAN	Inhibitor	[1]

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References

1	Chemogenomic identification of Ref-1/AP-1 as a therapeutic target for asthma. Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1169-73.
2	CenterWatch. Drugs in Clinical Trials Database. CenterWatch. 2008.
3	Diversity-oriented synthesis: exploring the intersections between chemistry and biology. Nat Chem Biol. 2005 Jul;1(2):74-84.
4	AP-1 blockade inhibits the growth of normal and malignant breast cells. Oncogene. 2001 May 17;20(22):2771-80.