Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDK7T9)

Drug Name
SBC-102 Drug Info
Synonyms Sebelipase alfa; Enzyme replacement therapy (protein recombinant, lysosomal acid lipase deficiency), Synageva BioPharma
Indication
Disease Entry ICD 11 Status REF
Enzyme deficiency 5C51-5C57 Approved [1]
Cross-matching ID
TTD Drug ID
DMDK7T9

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Lysosomal acid lipase (LIPA) TTS8T1M LICH_HUMAN Modulator [2]

References

1 ClinicalTrials.gov (NCT01757184) A Multicenter Study of SBC-102 (Sebelipase Alfa) in Patients With Lysosomal Acid Lipase Deficiency/ ARISE (Acid Lipase Replacement Investigating Safety and Efficacy).U.S. National Institutes of Health.
2 A Phase 3 Trial of Sebelipase Alfa in Lysosomal Acid Lipase Deficiency. N Engl J Med. 2015 Sep 10;373(11):1010-20.