Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDN4KP)

Drug Name	PMID29166791-Compound-AMPCP Drug Info
Cross-matching ID	TTD Drug ID DMDN4KP

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

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Drug(s) Targeting Ecto-5'-nucleotidase (CD73)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
TJ004309	DMFB54Y	Ovarian cancer	2C73	Phase 2	[2]
GS-1423	DMS25DL	Solid tumour/cancer	2A00-2F9Z	Phase 1	[3]
Oleclumab	DMLVNWO	Solid tumour/cancer	2A00-2F9Z	Phase 1	[4]
AB680	DMGONUE	Pancreatic cancer	2C10	Phase 1	[5]
TJ4309	DMM3U2Q	Solid tumour/cancer	2A00-2F9Z	Phase 1	[6]
CPI-006	DMJSFTX	Advanced cancer	2A00-2F9Z	Phase 1	[7]
LY3475070	DMZLIWX	Solid tumour/cancer	2A00-2F9Z	Phase 1	[8]
NZV930	DMWN2FP	Solid tumour/cancer	2A00-2F9Z	Phase 1	[9]
PMID28870136-Compound-57	DME3HLC	N. A.	N. A.	Patented	[10]
PMID28870136-Compound-46	DM4FD7C	N. A.	N. A.	Patented	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	Evaluation of WO2017098421: GSK's benzothiazine compounds as CD73 inhibitor filings.Expert Opin Ther Pat. 2018 Feb;28(2):167-171.
2	ClinicalTrials.gov (NCT05001347) A Phase 2 Clinical Study of TJ004309 in Combination With Atezolizumab (TECENTRIQ?) in Patients With Advanced or Metastatic Ovarian Cancers and Selected Advanced Solid Tumors. U.S.National Institutes of Health.
3	Clinical pipeline report, company report or official report of Agenus.
4	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5	Discovery of AB680: A Potent and Selective Inhibitor of CD73. J Med Chem. 2020 Oct 22;63(20):11448-11468.
6	ClinicalTrials.gov (NCT04322006) A Phase I/II Study of TJ004309 for Advanced Solid Tumor. U.S. National Institutes of Health.
7	Clinical pipeline report, company report or official report of Corvus Pharmaceuticals.
8	CD73's Potential as an Immunotherapy Target in Gastrointestinal Cancers. Front Immunol. 2020 Apr 15;11:508.
9	Clinical pipeline report, company report or official report of Surface oncology.
10	Ectonucleotidase inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2017 Dec;27(12):1291-1304.