Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDSCQG)

Drug Name

PF-04840082 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Osteoporosis	FB83.0	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Dickkopf-related protein 1 (DKK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BHQ880	DMSROM4	Multiple myeloma	2A83	Phase 2	[3]
DKN-01	DMOHT5V	Biliary tract cancer	2C17	Phase 2	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dickkopf-related protein 1 (DKK1)	TTE3RAC	DKK1_HUMAN	Modulator	[2]

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References

1	ClinicalTrials.gov (NCT01293487) Safety And Tolerability Study Of RN564 In Women With Osteopenia And Healthy Men.. U.S. National Institutes of Health.
2	The application of target information and preclinical pharmacokinetic/pharmacodynamic modeling in predicting clinical doses of a Dickkopf-1 antibody for osteoporosis. J Pharmacol Exp Ther. 2010 Apr;333(1):2-13.
3	Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma. Blood. 2009 Jul 9;114(2):371-9.
4	The anti-DKK1 antibody DKN-01 as an immunomodulatory combination partner for the treatment of cancer. Expert Opin Investig Drugs. 2020 Jul;29(7):639-644.