Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDSK9N)

Drug Name

GSK2801 Drug Info

Synonyms

KB-146016

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Bromodomain adjacent to zinc finger 2B (BAZ2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BAZ2-ICR	DMKDZLG	Discovery agent	N.A.	Investigative	[4]
PMID25719566C7	DMGCAIO	Discovery agent	N.A.	Investigative	[4]
PMID25719566C1	DM7AJER	Discovery agent	N.A.	Investigative	[4]
------------------------------------------------------------------------------------

Drug(s) Targeting Bromodomain adjacent to zinc finger 2A (BAZ2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BAZ2-ICR	DMKDZLG	Discovery agent	N.A.	Investigative	[4]
------------------------------------------------------------------------------------

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bromodomain adjacent to zinc finger 2A (BAZ2A)	TT2MV0R	BAZ2A_HUMAN	Inhibitor	[2]
Bromodomain adjacent to zinc finger 2B (BAZ2B)	TT6K8YG	BAZ2B_HUMAN	Inhibitor	[3]

------------------------------------------------------------------------------------

References

1	The NoRC complex mediates the heterochromatin formation and stability of silent rRNA genes and centromeric repeats. EMBO J. 2010 Jul 7;29(13):2135-46.
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2721).
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2722).
4	Structure enabled design of BAZ2-ICR, a chemical probe targeting the bromodomains of BAZ2A and BAZ2B. J Med Chem. 2015 Mar 12;58(5):2553-9.