Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDTONZ)

Drug Name

AVP-13546 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Autoimmune disease	4A40-4A45	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Preclinical Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Macrophage migration inhibitory factor (MIF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
3,4-Dihydroxycinnamic Acid	DMVZL26	Thrombocytopenia	3B64	Phase 4	[2]
Anti-MIF antibodies	DM8EKSV	Autoimmune diabetes	5A10	Phase 4	[3]
ISO-1	DMDB7KU	N. A.	N. A.	Phase 1	[4]
COR100140	DMN0GTR	Inflammation	1A00-CA43.1	Preclinical	[5]
6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE	DMPSOIF	Discovery agent	N.A.	Investigative	[6]
4-hydroxyphenylpyruvic acid	DM0564K	Discovery agent	N.A.	Investigative	[6]
AVP-13748	DMBNDYK	Autoimmune disease	4A40-4A45	Investigative	[1]
4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME	DM7WPGN	Discovery agent	N.A.	Investigative	[6]
NAPQI	DM8F5LR	Autoimmune disease	4A40-4A45	Investigative	[1]
------------------------------------------------------------------------------------


⏷ Show the Full List of 9 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Macrophage migration inhibitory factor (MIF)	TT2AST1	MIF_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

References

1	MIF in autoimmunity and novel therapeutic approaches. Autoimmun Rev. 2009 Jan;8(3):244-9.
2	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
3	Neutralization of Macrophage Migration Inhibitory Factor (MIF) by Fully Human Antibodies Correlates with Their Specificity for the beta-Sheet Structure of MIF. J Biol Chem. 2012 March 2; 287(10): 7446-7455.
4	The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents. J Biol Chem. 2002 Jul 12;277(28):24976-82.
5	Cortical Pty Ltd Presents MIF Antagonist Data at World Congress on Inflammation. Cortical Pty Ltd. 2005.
6	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.