General Information of Drug (ID: DMDV4EP)

Drug Name
Adagrasib Drug Info
Synonyms
2326521-71-3; MRTX-849; UNII-8EOO6HQF8Y; 8EOO6HQF8Y; 2-((S)-4-(7-(8-Chloronaphthalen-1-yl)-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-1-(2-fluoroacryloyl)piperazin-2-yl)acetonitrile; CHEMBL4594350; SCHEMBL20974691; GTPL10888; Kras G12C inhibitor MRTX849; BCP31538; EX-A3258; MRTX-849; MRTX 849; MFCD32263433; s8884; compound 20 [PMID: 32250617]; BS-16211; HY-130149; CS-0105265; 2-Piperazineacetonitrile, 4-(7-(8-chloro-1-naphthalenyl)-5,6,7,8-tetrahydro-2-(((2S)-1-methyl-2-pyrrolidinyl)methoxy)pyrido(3,4-d)pyrimidin-4-yl)-1-(2-fluoro-1-oxo-2-propen-1-yl)-, (2S)-
Indication
Disease Entry ICD 11 Status REF
Non-small-cell lung cancer 2C25 Approved [1]
Cross-matching ID
PubChem CID
138611145
CAS Number
CAS 2326521-71-3
TTD Drug ID
DMDV4EP

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sotorasib DMLSV74 Non-small-cell lung cancer 2C25 Approved [3]
JDQ443 DMHI7CQ Non-small-cell lung cancer 2C25 Phase 3 [4]
LY3499446 DMA1CSR Solid tumour/cancer 2A00-2F9Z Phase 1/2 [5]
RG6330 DMSX5NJ Solid tumour/cancer 2A00-2F9Z Phase 1 [6]
JNJ-74699157 DMY7CW1 Solid tumour/cancer 2A00-2F9Z Phase 1 [5]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
KRAS G12C mutant (KRAS G12C) TT3LH46 RASK_HUMAN Inhibitor [2]

References

1 FDA Approved Drug Products from FDA Official Website. 2022. Application Number: 216340.
2 Clinical pipeline report, company report or official report of Mirati Therapeutics.
3 Clinical pipeline report, company report or official report of Amgen.
4 Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C. Cancer Discov. 2022 Jun 2;12(6):1500-1517.
5 KRAS: From undruggable to a druggable Cancer Target. Cancer Treat Rev. 2020 Sep;89:102070.
6 Clinical pipeline report, company report or official report of Roche.