Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DME0NO8)

Drug Name

PYZD-4409 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
leukaemia	2A60-2B33	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

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Drug(s) Targeting Ubiquitin-activating enzyme E1 (UBAE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SCHEMBL15198145	DMKQ0GE	N. A.	N. A.	Patented	[2]
SCHEMBL15198146	DMHPQI2	N. A.	N. A.	Patented	[2]
QCPOIDRINIAUKU-SRBBEKPSSA-N	DM4DJA7	N. A.	N. A.	Patented	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Ubiquitin-activating enzyme E1 (UBAE1)	TTXHWA7	UBA1_HUMAN	Inhibitor	[1]

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References

1	The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma. Blood. 2010 Mar 18;115(11):2251-9.
2	Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme. US10202389.