Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DME2W4T)

Drug Name

Forodesine Drug Info

Synonyms

Immucillin H; Fodosine; Immucillin-H; 209799-67-7; BCX-1777; 1,4-dideoxy-4-aza-1-(s)-(9-deazahypoxanthin-9-yl)-d-ribitol; UNII-426X066ELK; CHEMBL218291; CHEBI:43362; 426X066ELK; (1S)-1,4-dideoxy-4-imino-(9-deazahypoxanthin-9-yl)-D-ribitol; IMH; 7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]-1,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one; (2R,3R,4S,5S)-2-(hydroxymethyl)-5-(4-hydroxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl)pyrrolidine-3,4-diol; Fodosine (TN)

Indication

Disease Entry	ICD 11	Status	REF
B-cell acute lymphoblastic leukaemia	2B33.3	Phase 1/2	[1]
Cutaneous T-cell lymphoma	2B01	Phase 1/2	[1]

Therapeutic Class

Anticancer Agents

Cross-matching ID

PubChem CID: 135409409
ChEBI ID: CHEBI:43362
CAS Number: CAS 209799-67-7
TTD Drug ID: DME2W4T

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Purine nucleoside phosphorylase (PNP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BCX-3408	DMRSG31	Autoimmune diabetes	5A10	Phase 2	[3]
2'3'-Dideoxyinosine	DMZWNQF	N. A.	N. A.	Phase 2	[4]
Guanosine	DM4T5LH	N. A.	N. A.	Phase 1	[4]
Peldesine	DMHV58T	N. A.	N. A.	Phase 1	[4]
CI-972	DM9ZBO0	Rheumatoid arthritis	FA20	Discontinued in Phase 1	[5]
7-tert-butyl-2, 3-dihydro-3, 3-dimethyl substituted dihydrofuran 30 (DHDMBF30)	DMSU06X	Discovery agent	N.A.	Investigative	[6]
Hypoxanthine	DMLSABI	Discovery agent	N.A.	Investigative	[4]
8-Iodo-Guanine	DM3K1EO	Discovery agent	N.A.	Investigative	[4]
8-Azaguanine	DM7VP90	Discovery agent	N.A.	Investigative	[4]
MT-Immucillin-H	DMK2FOX	Discovery agent	N.A.	Investigative	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Purine nucleoside phosphorylase (PNP)	TTMCF1Y	PNPH_HUMAN	Inhibitor	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8272).
2	Forodesine has high antitumor activity in chronic lymphocytic leukemia and activates p53-independent mitochondrial apoptosis by induction of p73 an... Blood. 2009 Aug 20;114(8):1563-75.
3	BCX-4208 (RO5092888), a Purine Nucleoside Phosphorylase (PNP) Inhibitor, Is a Novel, Potent Orally Active Anti-T-Cell and B-Cell Agent. 50th ASH Annual Meeting and Exposition. 2008.
4	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
5	Inhibitors of human purine nucleoside phosphorylase. Synthesis of pyrrolo[3,2-d]pyrimidines, a new class of purine nucleoside phosphorylase inhibitors as potentially T-cell selective immunosuppressive agents. Description of 2,6-diamino-3,5-dihydro-7-(3-thienylmethyl)-4H-pyrrolo[3,2-d] pyrimidin-4-one. J Med Chem. 1992 May 1;35(9):1605-9.
6	Expression of human malaria parasite purine nucleoside phosphorylase in host enzyme-deficient erythrocyte culture. Enzyme characterization and identification of novel inhibitors. J Biol Chem. 1986 Sep 5;261(25):11667-73.
7	Plasmodium falciparum purine nucleoside phosphorylase: crystal structures, immucillin inhibitors, and dual catalytic function. J Biol Chem. 2004 Apr 30;279(18):18103-6.