Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DME4NH1)

Drug Name

Di-imidazole lexitropsin Drug Info

Synonyms

DIIMIDAZOLE LEXITROPSIN; AC1NDQQ9; [1-amino-3-[[4-[(4-formamido-1-methylimidazole-2-carbonyl)amino]-1-methylimidazole-2-carbonyl]amino]propylidene]azanium

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 449424
CAS Number: CAS 114139-02-5
TTD Drug ID: DME4NH1

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Human Deoxyribonucleic acid minor groove (hDNA min)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lurbinectedin	DMEFRTZ	Small-cell lung cancer	2C25.Y	Approved	[2]
Brostallicin	DMUI5PA	Breast cancer	2C60-2C65	Phase 2	[3]
Duocarmycin	DM0CQIP	Discovery agent	N.A.	Investigative	[4]
Netropsin	DMOW2QS	Discovery agent	N.A.	Investigative	[5]
Distamycin A	DMPVNDK	Discovery agent	N.A.	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Human Deoxyribonucleic acid minor groove (hDNA min)	TTOVXHF	NOUNIPROTAC	Binder (minor groove binder)	[1]

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References

1	Defining GC-specificity in the minor groove: side-by-side binding of the di-imidazole lexitropsin to C-A-T-G-G-C-C-A-T-G. Structure. 1997 Aug 15;5(8):1033-46.
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
3	Brostallicin (PNU-166196), a new minor groove DNA binder: preclinical and clinical activity. Expert Opin Investig Drugs. 2009 Dec;18(12):1939-46.
4	Structural studies of atom-specific anticancer drugs acting on DNA. Pharmacol Ther. 1999 Sep;83(3):181-215.
5	Drug-DNA binding specificity: binding of netropsin and distamycin to poly(d2NH2A-dT). Biopolymers. 1990;30(1-2):223-7.
6	Development of distamycin-related DNA binding anticancer drugs. Expert Opin Investig Drugs. 2001 Sep;10(9):1703-14.