Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DME6OXB)

Drug Name

AKL-0707 Drug Info

Synonyms

Akela GHRH; LAB GHRH; GHRH analog, Akela; Malnutrition therapy, LAB International

Indication

Disease Entry	ICD 11	Status	REF
Lipodystrophy	EF01	Discontinued in Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Growth hormone-releasing hormone receptor (GHRHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sermorelin	DM25HP1	Pediatric growth disorder	FB86	Approved	[3]
Tesamorelin	DM9GP85	HIV-associated lipodystrophy	1C62.1	Approved	[4]
Examorelin	DMGJMQH	Growth hormone deficiency	5A61.3	Discontinued in Phase 2	[5]
L-692429	DMLHE5A	Growth hormone deficiency	5A61.3	Discontinued in Phase 1	[6]
NNC-26-0762	DMLTYFI	Growth hormone deficiency	5A61.3	Terminated	[7]
Mutated growth hormone	DMAY50R	Acromegaly	5A60.0	Investigative	[8]
------------------------------------------------------------------------------------


⏷ Show the Full List of 6 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Growth hormone-releasing hormone receptor (GHRHR)	TTG4R8V	GHRHR_HUMAN	Agonist	[2]

------------------------------------------------------------------------------------

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021539)
2	A super-agonist of growth hormone-releasing hormone causes rapid improvement of nutritional status in patients with chronic kidney disease. Kidney Int. 2010 Mar;77(5):450-8.
3	Sermorelin: a better approach to management of adult-onset growth hormone insufficiency Clin Interv Aging. 2006;1(4):307-8.
4	Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.
5	Hexarelin is a stronger GH-releasing peptide than GHRH in normal cycling women but not in anorexia nervosa. J Endocrinol Invest. 1997 May;20(5):257-63.
6	Nonpeptide and peptide growth hormone secretagogues act both as ghrelin receptor agonist and as positive or negative allosteric modulators of ghrel... Mol Endocrinol. 2005 Sep;19(9):2400-11.
7	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010046)
8	Treatment strategies for acromegaly. Expert Opin Emerg Drugs. 2005 Nov;10(4):875-90.