Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DME7PBN)

Drug Name

mRNA-3704 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Methylmalonic acidemia	5C50.E0	Phase 1/2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting Methylmalonyl-CoA mutase (MMUT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroxocobalamin	DMGKV9D	Cerebral edema	8D60.1	Approved	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Methylmalonyl-CoA mutase (MMUT)	TTCQ21Y	MUTA_HUMAN	Replacement	[2]

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References

1	ClinicalTrials.gov (NCT03810690) Open Label Study of mRNA-3704 in Patients With Isolated Methylmalonic Acidemia. U.S. National Institutes of Health.
2	Clinical pipeline report, company report or official report of Moderna Therapeutics.
3	Vitamin B12. Nippon Rinsho. 1999 Oct;57(10):2205-10.