Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DME8RNV)

Drug Name
OM-197-MP-AC Drug Info
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Investigative [1]
Cross-matching ID
TTD Drug ID
DME8RNV

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Toll-like receptor 4 (TLR4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
MPL-containing Pollinex allergy desensitization vaccine DMXSDJU Allergy 4A80-4A85 Preregistration [2]
Cadi-05 DMPTCYB Prostate cancer 2C82.0 Phase 3 [3]
Resatorvid DMFMWYC Sepsis 1G40-1G41 Phase 3 [4]
ERITORAN DMKQZ0L Sepsis 1G40-1G41 Phase 3 [5]
G100 DMKHNXA Non-hodgkin lymphoma 2B33.5 Phase 2 [6]
OM-174 DM2THBX Solid tumour/cancer 2A00-2F9Z Phase 1 [7]
NI-0101 DM31FOP Autoimmune diabetes 5A10 Phase 1 [1]
GSK1795091 DMC6QE4 Solid tumour/cancer 2A00-2F9Z Phase 1 [6]
CRX-675 DMHDSYF Hepatitis virus infection 1E50-1E51 Phase 1 [1]
CS-4771 DMVDLT4 Sepsis 1G40-1G41 Discontinued in Phase 1 [8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Toll-like receptor 4 (TLR4) TTISGCA TLR4_HUMAN Modulator [1]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1754).
2 Allergy Therapeutics PLC. News Announcement. Allergy Therapeutics. Clinical Trials. Allergy Therapeutics PLC. 11 October 2006.
3 Trial Watch: Experimental Toll-like receptor agonists for cancer therapy. Oncoimmunology. 2012 August 1; 1(5): 699-716.
4 Clinical pipeline report, company report or official report of Takeda (2009).
5 Small molecule modulators of toll-like receptors. J Med Chem. 2008 Nov 13;51(21):6621-6.
6 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
7 Phase I study of OM-174, a lipid A analogue, with assessment of immunological response, in patients with refractory solid tumors. BMC Cancer. 2013 Apr 2;13:172.
8 Eritoran insight for influenza treatment. SciBX 6(19); doi:10.1038/scibx.2013.453. May 16 2013