Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMEAI6V)

Drug Name

1-(3,5-difluorobenzyl)-1H-imidazole Drug Info

Synonyms

1-(3,5-difluorobenzyl)-1H-imidazole; CHEMBL446946; 170166-01-5; SCHEMBL10518956; CTK0E4909; DTXSID20474067; 1-(3,5-Difluorobenzyl)imidazole; ZINC36466875; BDBM50188089; AKOS027391623; 1-[(3,5-difluorophenyl)methyl]-1H-imidazole; 1H-Imidazole, 1-[(3,5-difluorophenyl)methyl]-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 11830301
CAS Number: CAS 170166-01-5
TTD Drug ID: DMEAI6V

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Steroid 17-alpha-monooxygenase (S17AH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Abiraterone acetate	DMANBZI	Prostate cancer	2C82.0	Approved	[2]
ABIRATERONE	DM8V75C	Prostate cancer	2C82.0	Approved	[3]
TAK-700	DM2H8FZ	Prostate cancer	2C82.0	Phase 3	[4]
TAVT-45	DMHBRGT	Prostate cancer	2C82.0	Phase 3	[5]
Seviteronel	DM9IMEZ	Breast cancer	2C60-2C65	Phase 2	[6]
CFG920	DM2BXDU	Prostate cancer	2C82.0	Phase 1/2	[7]
DST-2970	DM69ZBU	Prostate cancer	2C82.0	Phase 1	[8]
4'-(Pyridin-4-ylmethyl)biphenyl-3,4-diol	DM6Z5EK	Discovery agent	N.A.	Investigative	[9]
4-Indan-(1Z)-ylidenemethyl-pyridine	DM25DR7	Discovery agent	N.A.	Investigative	[10]
4-[(4'-Hydroxybiphenyl-4-yl)methyl]pyridine	DMIEMWA	Discovery agent	N.A.	Investigative	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Steroid 17-alpha-monooxygenase (S17AH)	TTRA5BZ	CP17A_HUMAN	Inhibitor	[1]

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References

1	Synthesis and biochemical evaluation of a range of potent benzyl imidazole-based compounds as potential inhibitors of the enzyme complex 17alpha-hy... Bioorg Med Chem Lett. 2006 Aug 1;16(15):4011-5.
2	CYP17A1 inhibitors in castration-resistant prostate cancer.Steroids.2015 Mar;95:80-7.
3	2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.
4	Orteronel (TAK-700), a novel non-steroidal 17,20-lyase inhibitor: effects on steroid synthesis in human and monkey adrenal cells and serum steroid levels in cynomolgus monkeys. J Steroid Biochem Mol Biol. 2012 Apr;129(3-5):115-28.
5	Clinical pipeline report, company report or official report of Tavanta Therapeutics
6	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
7	Recent progress in pharmaceutical therapies for castration-resistant prostate cancer. Int J Mol Sci. 2013 Jul 4;14(7):13958-78.
8	Clinical pipeline report, company report or official report of DisperSol Technologies.
9	Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prosta... J Med Chem. 2010 Aug 12;53(15):5749-58.
10	Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75.