Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMEARS2)

• Drug Name: US9200020, Table 3, Compound 1B Drug Info
• Synonyms: BDBM60886; US9200020, Table 3, Compound 1B
• Cross-matching ID:
  PubChem CID: 72672374
  TTD Drug ID: DMEARS2

Molecule-Related Drug Atlas

Drug(s) Targeting Plasmodium Hypoxanthine-guanine phosphoribosyltransferase (Malaria LACZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US9200020, Table 3, Compound 2B	DMXFB5Z	N. A.	N. A.	Patented	[1]
US9200020, Table 3 compound 8	DMCLHX5	N. A.	N. A.	Patented	[1]
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[2]
Formic Acid	DMNFZC6	Discovery agent	N.A.	Investigative	[2]
Pyrophosphate 2-	DMZQ75M	Discovery agent	N.A.	Investigative	[3]
Guanosine-5'-Monophosphate	DM3SLZK	Discovery agent	N.A.	Investigative	[2]
Inosinic Acid	DMLR86H	Discovery agent	N.A.	Investigative	[2]
Alpha-Phosphoribosylpyrophosphoric Acid	DMT6KI7	Discovery agent	N.A.	Investigative	[3]
Carboxylic PRPP	DMCTUR1	Discovery agent	N.A.	Investigative	[2]
5--Monophosphate-9-Beta-D-Ribofuranosyl Xanthine	DMX0EAK	Discovery agent	N.A.	Investigative	[2]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Plasmodium Hypoxanthine-guanine phosphoribosyltransferase (Malaria LACZ)	TTBL49X	HGXR_PLAFG	Inhibitor	[1]

References

• [1] 6-oxopurine phosphoribosyltransferase inhibitors. US9200020.
• [2] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [3] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.