Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMEIG16)

Drug Name
Tricyclic compound 4 Drug Info
Synonyms PMID28048944-Compound-23
Cross-matching ID
PubChem CID
129159093
TTD Drug ID
DMEIG16

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Rho-associated protein kinase 2 (ROCK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Belumosudil DM548TK Graft-versus-host disease 4B24 Approved [2]
INS-117548 DMA46DO Glaucoma/ocular hypertension 9C61 Phase 1 [3]
GSK269962A DM5I2HL Inflammation 1A00-CA43.1 Clinical trial [4]
PMID28048944-Compound-19 DMPT3V9 N. A. N. A. Patented [1]
PMID28048944-Compound-3 DM1BN74 N. A. N. A. Patented [1]
PMID28048944-Compound-7 DMXZ368 N. A. N. A. Patented [1]
PMID28048944-Compound-4 DMJAUWG N. A. N. A. Patented [1]
PMID28048944-Compound-5 DMAB987 N. A. N. A. Patented [1]
PMID28048944-Compound-6 DM5RCBV N. A. N. A. Patented [1]
PMID28048944-Compound-2 DM9ZXOP N. A. N. A. Patented [1]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Rho-associated protein kinase 2 (ROCK2) TTGWKQJ ROCK2_HUMAN Inhibitor [1]

References

1 Rho kinase inhibitors: a patent review (2014 - 2016).Expert Opin Ther Pat. 2017 Apr;27(4):507-515.
2 Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16814-9.
3 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
4 Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities. J Pharmacol Exp Ther. 2007 Jan;320(1):89-98.