Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMEJ107)

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

Investigative Drug(s)

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Drug(s) Targeting Bromodomain-containing protein 4 (BRD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CPI-0610	DMPXOYJ	Myelofibrosis	2A20.2	Phase 3	[2]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]
PLX2853	DMX168L	Acute myeloid leukaemia	2A60	Phase 1/2	[3]
RVX-208	DM1LO8K	Alzheimer disease	8A20	Phase 1/2	[2]
INCB57643	DMBGU7V	Advanced malignancy	2A00-2F9Z	Phase 1/2	[3]
ABBV-744	DMTEA9C	Acute myeloid leukaemia	2A60	Phase 1	[3]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[4]
GSK525762	DMPAWBN	Haematological malignancy	2B33.Y	Phase 1	[2]
TEN010	DM4UOY5	Advanced solid tumour	2A00-2F9Z	Phase 1	[2]
AZD5153	DMW4GM2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[3]
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Drug(s) Targeting Bromodomain-containing protein 3 (BRD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ABBV-744	DMTEA9C	Acute myeloid leukaemia	2A60	Phase 1	[3]
PMID26924192-Compound-104	DM346EU	N. A.	N. A.	Patented	[1]
PMID26924192-Compound-103	DMWOCP7	N. A.	N. A.	Patented	[1]
PMID26924192-Compound-105	DMAWLGI	N. A.	N. A.	Patented	[1]
Pyrrolo-pyrrolone derivative 1	DMN4SE5	N. A.	N. A.	Patented	[1]
XD14	DMUMACD	Discovery agent	N.A.	Investigative	[5]
GW841819X	DMRL9IN	Discovery agent	N.A.	Investigative	[6]
PMID24000170C36	DMHUWZS	Discovery agent	N.A.	Investigative	[7]
PMID24000170C38	DMOLRIY	Discovery agent	N.A.	Investigative	[7]
I-BET151	DMYRUH2	Discovery agent	N.A.	Investigative	[8]
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Drug(s) Targeting Bromodomain-containing protein 2 (BRD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]
ABBV-744	DMTEA9C	Acute myeloid leukaemia	2A60	Phase 1	[3]
PMID26924192-Compound-104	DM346EU	N. A.	N. A.	Patented	[1]
PMID26924192-Compound-103	DMWOCP7	N. A.	N. A.	Patented	[1]
PMID26924192-Compound-105	DMAWLGI	N. A.	N. A.	Patented	[1]
Pyrrolo-pyrrolone derivative 1	DMN4SE5	N. A.	N. A.	Patented	[1]
PMID26924192-Compound-106	DM9HRZJ	N. A.	N. A.	Patented	[1]
XD14	DMUMACD	Discovery agent	N.A.	Investigative	[5]
GW841819X	DMRL9IN	Discovery agent	N.A.	Investigative	[6]
PMID24000170C36	DMHUWZS	Discovery agent	N.A.	Investigative	[7]
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Drug(s) Targeting Bromodomain testis-specific protein (BRDT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[9]
PMID26924192-Compound-104	DM346EU	N. A.	N. A.	Patented	[1]
PMID26924192-Compound-103	DMWOCP7	N. A.	N. A.	Patented	[1]
PMID26924192-Compound-105	DMAWLGI	N. A.	N. A.	Patented	[1]
XD14	DMUMACD	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bromodomain testis-specific protein (BRDT)	TT7CPI5	BRDT_HUMAN	Inhibitor	[1]
Bromodomain-containing protein 2 (BRD2)	TTDP48B	BRD2_HUMAN	Inhibitor	[1]
Bromodomain-containing protein 3 (BRD3)	TTHE657	BRD3_HUMAN	Inhibitor	[1]
Bromodomain-containing protein 4 (BRD4)	TTRA6BO	BRD4_HUMAN	Inhibitor	[1]

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References

1	BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22.
2	Targeting bromodomains: epigenetic readers of lysine acetylation.Nat Rev Drug Discov.2014 May;13(5):337-56.
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	Selective inhibition of BET bromodomains. Nature. 2010 Dec 23;468(7327):1067-73.
5	4-Acyl pyrroles: mimicking acetylated lysines in histone code reading. Angew Chem Int Ed Engl. 2013 Dec 23;52(52):14055-9.
6	Discovery and characterization of small molecule inhibitors of the BET family bromodomains. J Med Chem. 2011 Jun 9;54(11):3827-38.
7	Naphthyridines as novel BET family bromodomain inhibitors. ChemMedChem. 2014 Mar;9(3):580-9.
8	Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. Nature. 2011 Oct 2;478(7370):529-33.
9	Small-molecule inhibition of BRDT for male contraception. Cell. 2012 Aug 17;150(4):673-84.