General Information of Drug (ID: DMEJNM1)

Drug Name
R-343 Drug Info
Synonyms R-921303; Syk tyrosine kinase inhibitor (allergic asthma), Rigel/Pfizer
Indication
Disease Entry ICD 11 Status REF
Asthma CA23 Discontinued in Phase 2 [1]
Cross-matching ID
PubChem CID
10344820
TTD Drug ID
DMEJNM1

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fostamatinib DM6AUHV Immune thrombocytopenic purpura 3B64.13 Approved [3]
Fostamatinib disodium DM3274D Thrombocytopenia 3B64 Phase 3 [4]
Cerdulatinib DMSCR2H B-cell lymphoma 2A86 Phase 2 [5]
TAK-659 DMJH3U0 Diffuse large B-cell lymphoma 2A81 Phase 2 [6]
GS-9876 DM9Q2B6 Cutaneous lupus erythematosus EB5Z Phase 2 [7]
GS-9973 DMKWCTR Acute myeloid leukaemia 2A60 Phase 2 [8]
Cevidoplenib DM9QU5G Rheumatoid arthritis FA20 Phase 2 [9]
HM43239 DMV1SDA Acute myeloid leukaemia 2A60 Phase 1/2 [10]
ALXN2075 DM1BSD8 Non-hodgkin lymphoma 2B33.5 Phase 1/2 [11]
SKI-O-703 DMTSKXR Rheumatoid arthritis FA20 Phase 1 [7]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Tyrosine-protein kinase SYK (SYK) TTOU65C KSYK_HUMAN Inhibitor [2]

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027577)
2 A novel Syk kinase inhibitor suitable for inhalation: R-343(. Expert Opin Ther Pat. 2009 Oct;19(10):1469-72.
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2230).
4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5 Company report (Portola Pharmaceuticals)
6 J Clin Oncol 32:5s, 2014 (suppl; abstr 8580).
7 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
8 An open-label phase 2 trial of entospletinib (GS-9973), a selective spleen tyrosine kinase inhibitor, in chronic lymphocytic leukemia. Blood. 2015 Apr 9;125(15):2336-43.
9 A novel selective spleen tyrosine kinase inhibitor SKI-O-703 (cevidoplenib) ameliorates lupus nephritis and serum-induced arthritis in murine models. Clin Exp Immunol. 2023 Mar 8;211(1):31-45.
10 Clinical pipeline report, company report or official report of Hanmi Pharmaceutical.
11 The Dual Syk/JAK Inhibitor Cerdulatinib Antagonizes B-cell Receptor and Microenvironmental Signaling in Chronic Lymphocytic Leukemia. Clin Cancer Res. 2017 May 1;23(9):2313-2324.