Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMELPJM)

Drug Name

EDD7H9 Drug Info

Synonyms

Anti S1P3 antibody (breast cancer), Expression Drug Designs; Anti-GPCR Abs (cancer), Expression Drug Designs; G-protein-coupled receptor inhibitor antibodies (breast cancer), Expression Drug Designs

Indication

Disease Entry	ICD 11	Status	REF
Breast cancer	2C60-2C65	Preclinical	[1]

Cross-matching ID

TTD Drug ID: DMELPJM

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

Download the Complete Related Drug List

Drug(s) Targeting Sphingosine-1-phosphate receptor 3 (S1PR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US9522888, 575	DM6UXZK	N. A.	N. A.	Patented	[3]
US9617250, Example 1 Example 204 of D1	DM89LKQ	N. A.	N. A.	Patented	[4]
YYDJCLCSBYCSCO-UHFFFAOYSA-N	DMA91FM	N. A.	N. A.	Patented	[5]
US9216972, 61	DM7AHQE	N. A.	N. A.	Patented	[6]
US9670220, 77	DMZG1HO	N. A.	N. A.	Patented	[7]
US10179791, Compound 296	DMLZBRM	N. A.	N. A.	Patented	[8]
JCXGHZCWAHCYGY-UHFFFAOYSA-N	DMER7QX	N. A.	N. A.	Patented	[5]
US9216972, 67	DMXR5SZ	N. A.	N. A.	Patented	[6]
US10166249, Example 695	DMVMNP1	N. A.	N. A.	Patented	[9]
US9181182, 40	DM3QIF4	N. A.	N. A.	Patented	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Sphingosine-1-phosphate receptor 3 (S1PR3)	TTDYP7I	S1PR3_HUMAN	Not Available	[2]

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References

1	Opportunities for therapeutic antibodies directed at G-protein-coupled receptors. Nat Rev Drug Discov. 2017 Sep;16(9):787-810.
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 277).
3	Substituted bicyclic compounds. US9522888.
4	Pyridin-4-yl derivatives. US9617250.
5	6-amino-pyrimidine-4-carboxamide derivatives and related compounds which bind to the sphingosine 1-phosphate (S1P) receptor for the treatment of multiple sclerosis. US9150519.
6	Tricyclic heterocyclic compounds. US9216972.
7	Fused heterocyclic derivatives as S1P modulators. US9670220.
8	Spiro-cyclic amine derivatives as S1P modulators. US10179791.
9	Substituted bicyclic compounds. US10166249.
10	S1P receptors modulators. US9181182.