Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMERJ6V)

Drug Name

PHX-1766 Drug Info

Synonyms

HCV protease inhibitors, Phenomix; Hepatitis c virus protease inhibitors, Phenomix; PHX-1176

Indication

Disease Entry	ICD 11	Status	REF
Hepatitis C virus infection	1E51.1	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Hepatitis C virus Serine protease NS4A (HCV NS4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
TG-2349	DMZ571Y	Hepatitis C virus infection	1E51.1	Phase 2	[3]
MK-6325	DMV8BI4	Hepatitis C virus infection	1E51.1	Phase 1	[4]
IDX-320	DMAYLS3	Hepatitis C virus infection	1E51.1	Discontinued in Phase 1/2	[5]
GS-9132	DMXB4T9	Hepatitis C virus infection	1E51.1	Discontinued in Phase 1/2	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Hepatitis C virus Serine protease NS4A (HCV NS4A)	TTRHUKY	POLG_HCV1	Modulator	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029167)
2	Pharmacokinetics and antiviral activity of PHX1766, a novel HCV protease inhibitor, using an accelerated Phase I study design. Antivir Ther. 2012;17(2):365-75.
3	Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
4	Synthesis of bis-macrocyclic HCV protease inhibitor MK-6325 via intramolecular sp -sp Suzuki-Miyaura coupling and ring closing metathesis. Org Lett. 2015 Mar 20;17(6):1533-6.
5	Rapid decline of viral RNA in chronic hepatitis C patients treated once daily with IDX320: a novel macrocyclic HCV protease inhibitor.Antivir Ther.2012;17(4):633-42.