Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMETNA3)

Drug Name

BMS-262084 Drug Info

Synonyms

BMS-262084; UNII-I0IR71971G; CHEMBL71037; I0IR71971G; 253174-92-4; (-)-BMS-262084; BDBM50120368; BDBM50220841; SB18716; 2-Azetidinecarboxylic acid, 3-(3-((aminoiminomethyl)amino)propyl)-1-((4-(((1,1-dimethylethyl)amino)carbonyl)-1-piperazinyl)carbonyl)-4-oxo-, (2S,3R)-; (R)-1-(4-tert-Butylcarbamoyl-piperazine-1-carbonyl)-3-(3-guanidino-propyl)-4-oxo-azetidine-2-carboxylic acid; (3S,4R)-1-(4-tert-Butylcarbamoyl-piperazine-1-carbonyl)-3-(3-guanidino-propyl)-4-oxo-azetidine-2-carboxylic acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 9802488
CAS Number: CAS 253174-92-4
TTD Drug ID: DMETNA3

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Tryptase alpha/beta-1 (Tryptase)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[2]
Lactoferrin	DMA7QTC	Solid tumour/cancer	2A00-2F9Z	Approved	[2]
APC-2059	DM8IB6K	Inflammatory bowel disease	DD72	Discontinued in Phase 2	[3]
APC-366	DM02DNQ	Asthma	CA23	Discontinued in Phase 2	[2]
BABIM	DM8AGOE	Asthma	CA23	Terminated	[2]
BAY-17-1998	DM7LZFQ	Asthma	CA23	Terminated	[4]
BAY-44-3428	DM40ORU	Asthma	CA23	Terminated	[5]
Grassystatin a	DM1PWX2	Discovery agent	N.A.	Investigative	[6]
AMG-126737	DM9H7AZ	Discovery agent	N.A.	Investigative	[7]
MOL 6131	DMSF8UC	Discovery agent	N.A.	Investigative	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Delta-tryptase (TPSD1)	TTNWD8O	TRYD_HUMAN	Inhibitor	[1]
Tryptase alpha/beta-1 (Tryptase)	TTM1TDX	TRYB1_HUMAN	Inhibitor	[1]

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References

1	Synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3229-33.
2	Inhibitors of tryptase for the treatment of mast cell-mediated diseases. Curr Pharm Des. 1998 Oct;4(5):381-96.
3	Treatment of mildly to moderately active ulcerative colitis with a tryptase inhibitor (APC 2059): an open-label pilot study. Aliment Pharmacol Ther. 2002 Mar;16(3):407-13.
4	Bayer AG to Develop Arris Asthma Compound; Arris to Receive Milestone Payment. 1996 Business Wire
5	Bayer AG to Develop Arris Asthma Compound; Arris to Receive Milestone Payment. 1996 Business Wire
6	Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation. J Med Chem. 2009 Sep 24;52(18):5732-47.
7	Tryptase inhibition blocks airway inflammation in a mouse asthma model. J Immunol. 2002 Feb 15;168(4):1992-2000.