Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMEWU6Z)

Drug Name

(2S)-aminobutyryl-L-proline-(2S)-methylbutylamide Drug Info

Synonyms

CHEMBL223719; (2S)-aminobutyryl-L-proline-(2S)-methylbutylamide

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Tripeptidyl-peptidase II (TPP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
UCL-2000; butabindide	DML51D0	Obesity	5B81	Discontinued in Phase 1	[2]
L-valyl-L-prolinamide	DMH7TNA	Discovery agent	N.A.	Investigative	[1]
(2S)-aminobutyryl-L-proline n-butylamide	DM12Q9O	Discovery agent	N.A.	Investigative	[1]
L-norvalyl-L-prolinamide	DMIXFGC	Discovery agent	N.A.	Investigative	[1]
L-valyl-L-proline benzylamide	DMQZ13A	Discovery agent	N.A.	Investigative	[1]
(2S)-aminobutyryl-L-prolinamide	DMG0QKL	Discovery agent	N.A.	Investigative	[1]
peptide 4	DM45RTZ	Discovery agent	N.A.	Investigative	[3]
example 8 [WO1999033801A1]	DMFSHXW	Discovery agent	N.A.	Investigative	[4]
(2S)-aminobutyryl-(R)-pipecolinic acid amide	DMWQK86	Discovery agent	N.A.	Investigative	[1]
L-norleucyl-L-prolinamide	DM7V30L	Discovery agent	N.A.	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tripeptidyl-peptidase II (TPP2)	TTQ7R2V	TPP2_HUMAN	Inhibitor	[1]

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References

1	Inhibitors of tripeptidyl peptidase II. 3. Derivation of butabindide by successive structure optimizations leading to a potential general approach ... J Med Chem. 2005 Nov 17;48(23):7333-42.
2	Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60.
3	Use of lantibiotic synthetases for the preparation of bioactive constrained peptides. Bioorg Med Chem Lett. 2008 May 15;18(10):3025-8.
4	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2423).