Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMEWUPF)

• Drug Name: Salmon Calcitonin Drug Info
• Synonyms: Astronin; Biocalcin; Bionocalcin; Cadens; Calciben; Calcihexal; Calcimar; Calcimonta; Calcinil; Calcioton; Calcitonina; Calcitoran; Calco; Calogen; Calsynar; Caltine; Casalm; Catonin; Cibacalcine; Citonina; Eptacalcin; Forcaltonin; Fortical; Ipocalcin; Kalsimin; Karil; Miacalcic; Miacalcin; Miracalcic; Oseototal; Osseocalcina; Osteobion; Osteovis; Ostosalm; Ostostabil; Porostenina; Prontocalcin; Quosten; Riostin; Rulicalcin; Salcat; Salcatonin; Salcatyn; Salmocalcin; Salmofar; Sical; Stalcin; Staporos; Steocin; Tonocalcin; Ucecal; Calcitonin salmon; Calcitonin vom lachs; Calcitonine de saumon; Calsynar Lyo L; Recombinant salmon calcitonin; Salmon calcitonin I; Synthetic salmon calcitonin; CALCITONIN, SALMON; Calcimar (TN); Calcitonin (salmon); Calcitonin salmon (synthesis); Calcitonin, salmar; Calcitonin,salmon; Calcitonin-salmon; Fortical (TN); Isi-calcin; Miacalcin (TN); TZ-CT; Thyrocalcitonin (salmon); Calcitonin salmon (USAN/INN); Calcitonin salmon (synthesis) (JAN); Calcitonin, salmon, for bioassay; Salmon calcitonin (1-32); Calcitonin [USAN:INN:BAN:JAN]; Salmon calcitonin-(I-32)

Indication

Disease Entry	ICD 11	Status	REF
Bone Paget disease		Approved	[1]
Osteoarthritis	FA00-FA05	Approved	[2]
Osteoporosis	FB83.0	Approved	[3]

• Therapeutic Class: Antiosteporotic Agents
• Cross-matching ID:
  PubChem CID: 16129616
  CAS Number: CAS 9007-12-9
  TTD Drug ID: DMEWUPF

Molecule-Related Drug Atlas

Drug(s) Targeting Calcitonin receptor (CALCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitonin Human	DM0N9WA	Paget's disease	FB85	Approved	[5]
DACRA 089	DM5TB76	Type 2 diabetes	5A11	Phase 1	[6]
LY 3541105	DMJ1X85	Obesity	5B81	Phase 1	[7]
TJN-220	DM4YQDX	Hypertension	BA00-BA04	Terminated	[8]
CSNLSTCVLGKLSQELc[DKLHK]YPRTNTGSGTP-amide	DMYDTO8	Discovery agent	N.A.	Investigative	[9]
CGNLSTCMLGTYTQDFNKPHTFPQTAIGVGAP-amide	DME84PN	Discovery agent	N.A.	Investigative	[9]
CGNLSTCMLGTYTQDFc[DKFHK]FPQTAIGVGAP-amide	DMUGAYT	Discovery agent	N.A.	Investigative	[9]
CSNLSTCVLGKLSQELc[DKLHO]YPRTNTGSGTP-amide	DMQXEHJ	Discovery agent	N.A.	Investigative	[9]
CGNLSTCMLGTYTQDFNKFHTFPQTAIGVGAP-amide	DMJ9Z31	Discovery agent	N.A.	Investigative	[9]
CGNLSTCBLGTYTQDF[DKFHO]YPQTAIGVGAP-amide	DMQ3SAY	Discovery agent	N.A.	Investigative	[9]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Calcitonin receptor (CALCR)	TTLWS2O	CALCR_HUMAN	Binder	[4]

References

• [1] Calcitonin. 2023 Aug 17. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 JanC.
• [2] Salmon calcitonin: a review of current and future therapeutic indications. Osteoporos Int. 2008 Apr;19(4):479-91.
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6973).
• [4] Improved absorption of salmon calcitonin by ultraflexible liposomes through intranasal delivery. Peptides. 2009 Jul;30(7):1288-95.
• [5] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [6] A novel dual amylin and calcitonin receptor agonist, KBP-089, induces weight loss through a reduction in fat, but not lean mass, while improving food preference. Br J Pharmacol. 2017 Apr;174(7):591-602.
• [7] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2023. Adis Insight
• [8] Evaluation of the long-lasting antihypertensive action of 7-O-ethylfangchinoline. Jpn J Pharmacol. 1994 Sep;66(1):35-46.
• [9] Side-chain lactam-bridge conformational constraints differentiate the activities of salmon and human calcitonins and reveal a new design concept fo... J Med Chem. 2002 Feb 28;45(5):1108-21.