Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMEWXFK)

Drug Name

C 82 Drug Info

Synonyms

N-(4-Chlorophenyl)-2H-triazol-4-amine; SCHEMBL15831502; C82

Indication

Disease Entry	ICD 11	Status	REF
Scleroderma	4A42	Phase 1/2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

Investigative Drug(s)

Approved Drug(s)

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Drug(s) Targeting CREB-binding protein (CREBBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CCS1477	DM9UZM1	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[2]
PRI-724	DM0HTEF	Acute myeloid leukaemia	2A60	Phase 1/2	[3]
FT-7051	DMCK3OI	Prostate cancer	2C82.0	Phase 1	[4]
Pyrrolo-pyrrolone derivative 6	DMBW208	N. A.	N. A.	Patented	[5]
SGC-CBP30	DMTLRGZ	Discovery agent	N.A.	Investigative	[6]
I-CBP112	DMQX3W6	Discovery agent	N.A.	Investigative	[7]
ischemin	DMM2I9G	Discovery agent	N.A.	Investigative	[8]
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Drug(s) Targeting Beta-catenin (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Recombinant human endostatin	DMMPCFX	Solid tumour/cancer	2A00-2F9Z	Approved	[9]
CEQ-508	DMCR7EF	Familial adenomatous polyposis	2B90.Y	Phase 1/2	[10]
Tegavivint	DMPJ3YX	Desmoid tumour	2F7C	Phase 1	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Targeting the p300/CBP Axis in Lethal Prostate Cancer. Cancer Discov. 2021 May;11(5):1118-1137.
3	Inhibition of Wnt/beta-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis. Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14309-14.
4	Clinical pipeline report, company report or official report of FORMA Therapeutics.
5	BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22.
6	Bromodomains and their pharmacological inhibitors. ChemMedChem. 2014 Mar;9(3):438-64.
7	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2734).
8	A small molecule binding to the coactivator CREB-binding protein blocks apoptosis in cardiomyocytes. Chem Biol. 2011 Apr 22;18(4):531-41.
9	Endostar, a modified recombinant human endostatin, suppresses angiogenesis through inhibition of Wnt/beta-catenin signaling pathway. PLoS One. 2014 Sep 18;9(9):e107463.
10	Current Progress of siRNA/shRNA Therapeutics in Clinical Trials. Biotechnol J. 2011 September; 6(9): 1130-1146.
11	Tegavivint and the beta-Catenin/ALDH Axis in Chemotherapy-Resistant and Metastatic Osteosarcoma. J Natl Cancer Inst. 2019 Nov 1;111(11):1216-1227.