General Information of Drug (ID: DMF9ALP)

Drug Name
BAY 1817080 Drug Info
Synonyms Eliapixant
Indication
Disease Entry ICD 11 Status REF
Cough MD12 Phase 1 [1]
Endometriosis GA10 Phase 1 [1]
Cross-matching ID
PubChem CID
121397587
TTD Drug ID
DMF9ALP

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Drug(s) Targeting P2X purinoceptor 3 (P2RX3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefapixant DM4GWL7 Cough MD12 Phase 3 [3]
BAY-1902607 DMYSQMW Cough MD12 Phase 2 [3]
BAY 1902607 DMFA4CK Cough MD12 Phase 1/2 [3]
AF-130 DM8LG2I Hypertension BA00-BA04 Phase 1 [4]
BAY-1817080 DMNL5G7 Endometriosis GA10 Phase 1 [3]
BzATP DM37GYA Discovery agent N.A. Investigative [5]
TNP-ATP DMVZY0X Discovery agent N.A. Investigative [6]
ISOPPADS DMWI0M8 Discovery agent N.A. Investigative [7]
LVAYPWT DMIO405 Discovery agent N.A. Investigative [8]
MK-3901 DM5EQ7F Pain MG30-MG3Z Investigative [5]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
P2X purinoceptor 3 (P2RX3) TT2THBD P2RX3_HUMAN Antagonist [2]

References

1 ClinicalTrials.gov (NCT04471337) Study on the Safety of BAY1817080 How it is Tolerated and the Way the Body Absorbs, Distributes and Gets Rid of the Study Drug Given to Participants With Moderate Renal Impairment and End Stage Renal Disease Requiring Dialysis Compared With Matched Participants With Normal Renal Function. U.S. National Institutes of Health.
2 Eliapixant (BAY 1817080), a P2X3 receptor antagonist, in refractory chronic cough: a randomised, placebo-controlled, crossover phase 2a study. Eur Respir J. 2021 May 13;2004240.
3 Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 480).
6 Trinitrophenyl-substituted nucleotides are potent antagonists selective for P2X1, P2X3, and heteromeric P2X2/3 receptors. Mol Pharmacol. 1998 Jun;53(6):969-73.
7 Structure-activity relationships of pyridoxal phosphate derivatives as potent and selective antagonists of P2X1 receptors. J Med Chem. 2001 Feb 1;44(3):340-9.
8 Structure-activity relationship studies of spinorphin as a potent and selective human P2X(3) receptor antagonist. J Med Chem. 2007 Sep 6;50(18):4543-7.