General Information of Drug (ID: DMF9W41)

Drug Name
example 20 (WO2010128058) Drug Info
Synonyms SCHEMBL297687; GTPL7853; example 20 [WO2010128058]
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
46944265
TTD Drug ID
DMF9W41

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
example 98 (WO2011020806) DM2N653 Focal segmental glomerulosclerosis MF8Y Clinical trial [3]
PMID21907142CJ DMST0IN Discovery agent N.A. Investigative [4]
example 2 (WO2013004676) DMU25HZ Discovery agent N.A. Investigative [5]
example 41 (WO2012028563) DM2N9Y8 Discovery agent N.A. Investigative [2]
2ewy DMNOAJG Discovery agent N.A. Investigative [6]
example 92 (WO2012095521) DMU42CR Discovery agent N.A. Investigative [2]
⏷ Show the Full List of 6 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Beta-site APP-cleaving enzyme 2 (BACE2) TT69DB8 BACE2_HUMAN Inhibitor [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7853).
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2331).
3 BACE2 as a new diabetes target: a patent review (2010 - 2012). Expert Opin Ther Pat. 2013 May;23(5):649-63.
4 Bace2 is a beta cell-enriched protease that regulates pancreatic beta cell function and mass. Cell Metab. 2011 Sep 7;14(3):365-77.
5 Cyclopropyl-Fused 1,3-Thiazepines as BACE1 and BACE2 Inhibitors. ACS Med Chem Lett. 2013 Mar 15;4(4):379-80.
6 Crystal structure of human BACE2 in complex with a hydroxyethylamine transition-state inhibitor. J Mol Biol. 2006 Jan 13;355(2):249-61.