Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFEZHM)

Drug Name
ISIS 116360 Drug Info
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
TTD Drug ID
DMFEZHM

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Cot oncogene messenger RNA (MAP3K8 mRNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
8-chloro-quinoline-3-carbonitrile DMFNUHQ Discovery agent N.A. Investigative [2]
NSC-686549 DM0164B Discovery agent N.A. Investigative [3]
ISIS 116361 DMWBQHS Discovery agent N.A. Investigative [1]
Tpl2 kinase inhibitor DMHATCZ Discovery agent N.A. Investigative [4]
ISIS 116414 DM4Q3JO Discovery agent N.A. Investigative [1]
ISIS 116359 DM280AE Discovery agent N.A. Investigative [1]
ISIS 116362 DM7M1UB Discovery agent N.A. Investigative [1]
ISIS 116363 DMXKAJP Discovery agent N.A. Investigative [1]
⏷ Show the Full List of 8 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cot oncogene messenger RNA (MAP3K8 mRNA) TTGECUM M3K8_HUMAN Not Available [1]

References

1 US patent application no. 6,265,216, Antisense modulation of cot oncogene expression.
2 Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood. J Biol Chem. 2007 Nov 16;282(46):33295-304.
3 A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8.
4 Inhibition of Tpl2 kinase and TNF-alpha production with 1,7-naphthyridine-3-carbonitriles: synthesis and structure-activity relationships. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5288-92.