General Information of Drug (ID: DMFG6MU)

Drug Name
N-(4-Chloro-3-methanesulfonyl-benzoyl)-guanidine Drug Info
Synonyms CHEMBL62469
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
19096151
TTD Drug ID
DMFG6MU

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Approved Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zoniporide hydrochloride DM8L7JD Angina pectoris BA40 Phase 3 [2]
CARIPORIDE DMV2DY3 Angina pectoris BA40 Discontinued in Phase 2 [3]
ENIPORIDE DME7OCX Cardiac arrhythmias BC9Z Discontinued in Phase 2 [4]
HOE-694 DML0B97 Heart arrhythmia BC65 Terminated [1]
N-(3-Methanesulfonyl-4-methyl-benzoyl)-guanidine DMSVQJP Discovery agent N.A. Investigative [1]
N-(4-Cyano-3-methanesulfonyl-benzoyl)-guanidine DMGI9EA Discovery agent N.A. Investigative [1]
N-(4-Bromo-3-methanesulfonyl-benzoyl)-guanidine DMC28SN Discovery agent N.A. Investigative [1]
N-(3-Methanesulfonyl-4-methoxy-benzoyl)-guanidine DM0H8CK Discovery agent N.A. Investigative [1]
N-(5-Methanesulfonyl-2-methyl-benzoyl)-guanidine DM91463 Discovery agent N.A. Investigative [1]
N-[2-(1H-benzoimidazol-2-yl)-benzoyl]-guanidine DMI9GQV Discovery agent N.A. Investigative [5]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tenapanor DMCOZJY Irritable bowel syndrome DD91.0 Approved [6]
AVE-0657 DMESMHU Cheyne-stokes respiration MD11.Y Phase 2 [7]
AZD1772//RDX5791 DMX5SG7 Chronic kidney disease GB61 Phase 2 [8]
CARIPORIDE DMV2DY3 Angina pectoris BA40 Discontinued in Phase 2 [4]
ENIPORIDE DME7OCX Cardiac arrhythmias BC9Z Discontinued in Phase 2 [4]
HOE-694 DML0B97 Heart arrhythmia BC65 Terminated [1]
N-(3-Methanesulfonyl-4-methyl-benzoyl)-guanidine DMSVQJP Discovery agent N.A. Investigative [1]
N-(4-Cyano-3-methanesulfonyl-benzoyl)-guanidine DMGI9EA Discovery agent N.A. Investigative [1]
N-(4-Bromo-3-methanesulfonyl-benzoyl)-guanidine DMC28SN Discovery agent N.A. Investigative [1]
N-(3-Methanesulfonyl-4-methoxy-benzoyl)-guanidine DM0H8CK Discovery agent N.A. Investigative [1]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Sodium/hydrogen exchanger 1 (SLC9A1) TTGSEFH SL9A1_HUMAN Inhibitor [1]
Sodium/hydrogen exchanger 3 (SLC9A3) TTFZVPO SL9A3_HUMAN Inhibitor [1]

References

1 (2-Methyl-5-(methylsulfonyl)benzoyl)guanidine Na+/H+ antiporter inhibitors. J Med Chem. 1997 Jun 20;40(13):2017-34.
2 Zoniporde: a potent and selective inhibitor of the human sodium-hydrogen exchanger isoform 1 (NHE-1). Cardiovasc Drug Rev. 2003 Spring;21(1):17-32.
3 Synthesis and bioactivity of substituted indan-1-ylideneaminoguanidine derivatives. Eur J Med Chem. 2009 Sep;44(9):3771-6.
4 Bicyclic acylguanidine Na+/H+ antiporter inhibitors. J Med Chem. 1998 Sep 10;41(19):3736-47.
5 Benzimidazol-2-yl or benzimidazol-2-ylthiomethyl benzoylguanidines as novel Na+/H+ exchanger inhibitors, synthesis and protection against ischemic-... Bioorg Med Chem Lett. 2007 May 1;17(9):2430-3.
6 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
7 Inhibition of central Na(+)/H(+) exchanger type 3 can alleviate sleep apnea in Sprague-Dawley rats. Chin Med J (Engl). 2014;127(1):48-53.
8 RDX5791, a First-in-Class Minimally Systemic NHE3 Inhibitor in Clinical Development for CIC and IBS-C, Increases Intestinal Sodium Leading to Enhanced Intestinal Fluid Volume and Transit. Gastroenterology. 2011;140(suppl 1):S99.