Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFHR2O)

Drug Name

XR-1853 Drug Info

Synonyms

XR 1853; XR-1853; AC1O5RT5; 3-((4-(2-(Dimethylamino)ethoxy)phenyl)methylene)-6-(phenylmethylene)-2,5-piperazinedione; 158944-02-6

Indication

Disease Entry	ICD 11	Status	REF
Thrombosis	DB61-GB90	Terminated	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Plasminogen activator inhibitor (PAI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aleplasinin	DMYTIP4	Alzheimer disease	8A20	Phase 1	[3]
T-686	DMOGQ2L	Arteriosclerosis	BD40	Terminated	[4]
XR-5082	DMEVSZO	Thrombosis	DB61-GB90	Terminated	[5]
BX-044	DM0P8CE	Thrombosis	DB61-GB90	Terminated	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Plasminogen activator inhibitor (PAI)	TT5QA2I	PAI1_HUMAN; PAI2_HUMAN; IPSP_HUMAN	Modulator	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006899)
2	Characterization and comparative evaluation of a novel PAI-1 inhibitor. Thromb Haemost. 2002 Jul;88(1):137-43.
3	CN patent application no. 102046168, Pai-1 expression and activity inhibitors for the treatment of ocular disorders.
4	T-686, a novel inhibitor of plasminogen activator inhibitor-1, inhibits thrombosis without impairment of hemostasis in rats. Eur J Pharmacol. 1997 Jul 9;330(2-3):151-6.
5	Evaluation of a low molecular weight modulator of human plasminogen activator inhibitor-1 activity. Thromb Haemost. 1996 May;75(5):808-15.
6	Characterization of a small molecule PAI-1 inhibitor, ZK4044. Thromb Res. 2005;115(4):341-50.