Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFKV97)

Drug Name

AC1LG8KT Drug Info

Synonyms

BAS 01816608; TCS JNK 5a

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

Investigative Drug(s)

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Drug(s) Targeting Stress-activated protein kinase JNK3 (JNK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID25991433-Compound-A1	DM89LF0	N. A.	N. A.	Patented	[4]
PMID25991433-Compound-F2	DM37VIQ	N. A.	N. A.	Patented	[4]
7-azaindole derivative 1	DMQL5B7	N. A.	N. A.	Patented	[4]
7-azaindole derivative 5	DMV3H98	N. A.	N. A.	Patented	[4]
PMID25991433-Compound-P6	DMNDVC9	N. A.	N. A.	Patented	[4]
PMID25991433-Compound-J3	DM17P3F	N. A.	N. A.	Patented	[4]
PMID25991433-Compound-P1	DMD8AX6	N. A.	N. A.	Patented	[4]
PMID25991433-Compound-O3	DMVOWS5	N. A.	N. A.	Patented	[4]
PMID25991433-Compound-J2	DMZSOCK	N. A.	N. A.	Patented	[4]
7-azaindole derivative 3	DMQ7BV4	N. A.	N. A.	Patented	[4]
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Drug(s) Targeting JNK2 messenger RNA (JNK2 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
N-(4-amino-5-cyano-6-phenylpyridin-2-yl)acetamide	DMUFVM6	Discovery agent	N.A.	Investigative	[5]
AS-601245	DMQ95EB	Discovery agent	N.A.	Investigative	[6]
Aminopyridine deriv. 2	DM94KQP	Discovery agent	N.A.	Investigative	[5]
IN-1166	DMMS6D3	Discovery agent	N.A.	Investigative	[7]
N-(4-amino-5-cyano-6-ethoxypyridin-2-yl)acetamide	DMY1FMG	Discovery agent	N.A.	Investigative	[5]
JNK-IN-8	DMLWYJB	Discovery agent	N.A.	Investigative	[8]
N-(4-amino-6-butoxy-5-cyanopyridin-2-yl)acetamide	DMSAD87	Discovery agent	N.A.	Investigative	[5]
ISIS 18078	DMHZPJ0	Solid tumour/cancer	2A00-2F9Z	Investigative	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
JNK2 messenger RNA (JNK2 mRNA)	TT3IVG2	MK09_HUMAN	Inhibitor	[2]
Stress-activated protein kinase JNK3 (JNK3)	TT056SO	MK10_HUMAN	Inhibitor	[3]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5996).
2	N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1296-301.
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1498).
4	c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72.
5	Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. J Med Chem. 2006 Jun 15;49(12):3563-80.
6	The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315.
7	Synthesis and biological evaluation of 4(5)-(6-alkylpyridin-2-yl)imidazoles as transforming growth factor-beta type 1 receptor kinase inhibitors. J Med Chem. 2007 Jun 28;50(13):3143-7.
8	Discovery of potent and selective covalent inhibitors of JNK. Chem Biol. 2012 Jan 27;19(1):140-54.
9	US patent application no. 7,425,545, Modulation of C-reactive protein expression.