Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFKWRM)

Drug Name

DIHYDROXANTHOHUMOL Drug Info

Synonyms

dihydroxanthohumol; alpha,beta-dihydroxanthohumol; MLS000863606; 4,2',4'-Trihydroxy-6'-methoxy-3'-prenyldihydrochalcone; CHEBI:66332; SMR000440746; a,b-Dihydroxanthohumol; MEGxp0_001797; CHEMBL510279; SCHEMBL15704299; BDBM76566; ACon1_000059; cid_10450920; HMS2267A19; LMPK12120536; 1-[2,4-dihydroxy-6-methoxy-3-(3-methylbut-2-enyl)phenyl]-3-(4-hydroxyphenyl)propan-1-one; NCGC00168833-01; BRD-K15951006-001-01-4; 2',4,4'-Trihydroxy-6'-methoxy-3'-prenyldihydrochalcone

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 10450920
ChEBI ID: CHEBI:66332
CAS Number: CAS 102448-00-0
TTD Drug ID: DMFKWRM

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

Download the Complete Related Drug List

Drug(s) Targeting Calpain-2 (CAPN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ABT-957	DMB9N4J	Alzheimer disease	8A20	Phase 1	[2]
PMID25399719-Compound-17	DMRXKJZ	N. A.	N. A.	Patented	[3]
Epoxysuccinate derivative 9	DM49FU0	N. A.	N. A.	Patented	[3]
Epoxysuccinate derivative 4	DMCF6M8	N. A.	N. A.	Patented	[3]
Carboxamide derivative 7	DM8TQS4	N. A.	N. A.	Patented	[3]
Epoxysuccinate derivative 7	DMTSPVF	N. A.	N. A.	Patented	[3]
Carboxamide derivative 10	DM5WMO9	N. A.	N. A.	Patented	[3]
Carboxamide derivative 11	DM1DN94	N. A.	N. A.	Patented	[3]
Carboxamide derivative 8	DM6HI34	N. A.	N. A.	Patented	[3]
Epoxysuccinate derivative 10	DMYF39U	N. A.	N. A.	Patented	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Calpain-2 (CAPN2)	TTG5QB7	CAN2_HUMAN	Inhibitor	[1]

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References

1	In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6.
2	Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
3	An updated patent review of calpain inhibitors (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):17-31.