Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFLP21)

Drug Name

MK 8719 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Progressive supranuclear palsy	8A00.10	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Beta-N-acetylhexosaminidase (OGA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LY3372689	DMA2M7V	Alzheimer disease	8A20	Phase 2	[2]
MK-8719	DMETIBD	Progressive supranuclear palsy	8A00.10	Phase 1	[3]
ASN51	DMZWOYL	Alzheimer disease	8A20	Phase 1	[4]
BIIB113	DM7U1AC	Alzheimer disease	8A20	Phase 1	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Beta-N-acetylhexosaminidase (OGA)	TT2I6UX	OGA_HUMAN	Inhibitor	[1]

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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	ClinicalTrials.gov (NCT05063539) Assessment of Safety, Tolerability, and Efficacy of LY3372689 in Early Symptomatic Alzheimer's Disease. U.S.National Institutes of Health.
3	Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies. J Med Chem. 2019 Nov 27;62(22):10062-10097.
4	Clinical pipeline report, company report or official report of Asceneuron
5	ClinicalTrials.gov (NCT05195008) A Phase 1 Randomized, Blinded, Placebo-Controlled, Single- and Multiple-Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics, With an Open-Label Target Occupancy Study of BIIB113 in Healthy Participants. U.S.National Institutes of Health.