Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFNSHM)

Drug Name

LHF-535 Drug Info

Synonyms

BET7FM8SQG; UNII-BET7FM8SQG; 1450929-77-7; (Z)-2-(4-(2-(1-(4-Isopropoxyphenyl)-1H-benzo[d]imidazol-5-yl)vinyl)phenyl)propan-2-ol; CHEMBL4537239; SCHEMBL15201523; HY-112762; CS-0063343; 2-[4-[(Z)-2-[1-(4-propan-2-yloxyphenyl)benzimidazol-5-yl]ethenyl]phenyl]propan-2-ol; Benzenemethanol, alpha,alpha-dimethyl-4-((1Z)-2-(1-(4-(1-methylethoxy)phenyl)-1H-benzimidazol-5-yl)ethenyl)-

Indication

Disease Entry	ICD 11	Status	REF
Lassa fever	1D61.2	Phase 1	[1]

Cross-matching ID

PubChem CID: 71711529
CAS Number: CAS 1450929-77-7
TTD Drug ID: DMFNSHM

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Lassa virus Pre-glycoprotein polyprotein GP complex (LASV GPC)	TTD2IK3	GLYC_LASSG	Inhibitor	[2]

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References

1	ClinicalTrials.gov (NCT03993704) Multiple Ascending Oral Dose 14-Day Trial of LHF-535 in Healthy Participants. U.S. National Institutes of Health.
2	A potent Lassa virus antiviral targets an arenavirus virulence determinant. PLoS Pathog. 2018 Dec 21;14(12):e1007439.