Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFSHXW)

Drug Name

example 8 [WO1999033801A1] Drug Info

Synonyms

example 8 [WO1999033801A1]; GTPL8581

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Discontinued Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Tripeptidyl-peptidase II (TPP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
UCL-2000; butabindide	DML51D0	Obesity	5B81	Discontinued in Phase 1	[3]
(2S)-aminobutyryl-L-proline-(2S)-methylbutylamide	DMEWU6Z	Discovery agent	N.A.	Investigative	[4]
L-valyl-L-prolinamide	DMH7TNA	Discovery agent	N.A.	Investigative	[4]
(2S)-aminobutyryl-L-proline n-butylamide	DM12Q9O	Discovery agent	N.A.	Investigative	[4]
L-norvalyl-L-prolinamide	DMIXFGC	Discovery agent	N.A.	Investigative	[4]
L-valyl-L-proline benzylamide	DMQZ13A	Discovery agent	N.A.	Investigative	[4]
(2S)-aminobutyryl-L-prolinamide	DMG0QKL	Discovery agent	N.A.	Investigative	[4]
peptide 4	DM45RTZ	Discovery agent	N.A.	Investigative	[5]
(2S)-aminobutyryl-(R)-pipecolinic acid amide	DMWQK86	Discovery agent	N.A.	Investigative	[4]
L-norleucyl-L-prolinamide	DM7V30L	Discovery agent	N.A.	Investigative	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tripeptidyl-peptidase II (TPP2)	TTQ7R2V	TPP2_HUMAN	Inhibitor	[2]

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References

1	Structure and function of tripeptidyl peptidase II, a giant cytosolic protease. Biochim Biophys Acta. 2012 Jan;1824(1):237-45.
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2423).
3	Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60.
4	Inhibitors of tripeptidyl peptidase II. 3. Derivation of butabindide by successive structure optimizations leading to a potential general approach ... J Med Chem. 2005 Nov 17;48(23):7333-42.
5	Use of lantibiotic synthetases for the preparation of bioactive constrained peptides. Bioorg Med Chem Lett. 2008 May 15;18(10):3025-8.