Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFT5D6)

Drug Name

Telcagepant Drug Info

Synonyms

MK 0974; MK0974; N7R; MK-0974; Telcagepant (USAN); N-(6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl)-4-(2-oxo-2,3-dihydro-1H-imidazo(4,5-b)pyridin-1-yl)piperidine-1-carboxamide

Indication

Disease Entry	ICD 11	Status	REF
Cluster headache	8A81.0	Phase 2	[1]
Migraine	8A80	Phase 2	[1]

Cross-matching ID

PubChem CID: 11319053
CAS Number: CAS 781649-09-0
TTD Drug ID: DMFT5D6

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Calcitonin gene-related peptide receptor (CGRPR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ubrogepant	DM749I3	Migraine	8A80	Approved	[3]
Fremanezumab	DMDZY54	Hyperprolactinaemia	5A60.1	Approved	[4]
Galcanezumab	DMIZ1E8	Hyperprolactinaemia	5A60.1	Approved	[4]
Erenumab	DMWMCN0	Hyperprolactinaemia	5A60.1	Approved	[4]
Rimegepant	DMHOAUG	Migraine	8A80	Approved	[5]
MK-3207	DM6OLGC	Migraine	8A80	Phase 2	[6]
AMG 334	DMI3WFG	Migraine	8A80	Phase 2	[7]
Olcegepant	DMVW5KR	Migraine	8A80	Phase 2	[8]
BI-44370	DMZR9OU	Migraine	8A80	Phase 2	[9]
LBR-101	DM4YA0D	Migraine	8A80	Phase 1	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Calcitonin gene-related peptide receptor (CGRPR)	TTY6O0Q	CALRL_HUMAN	Antagonist	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 703).
2	CGRP antagonists: novel concept for treatment of migraine. Med Monatsschr Pharm. 2009 May;32(5):182-5.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
4	2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
5	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
6	Pharmacological properties of MK-3207, a potent and orally active calcitonin gene-related peptide receptor antagonist. J Pharmacol Exp Ther. 2010 Apr;333(1):152-60.
7	EHMTI-0315. AMG 334, the first potent and selective human monoclonal antibody antagonist against the CGRP receptor. J Headache Pain. 2014; 15(Suppl 1): G43.
8	Olcegepant, a non-peptide CGRP1 antagonist for migraine treatment. IDrugs. 2007 Aug;10(8):566-74.
9	BI 44370 TA, an oral CGRP antagonist for the treatment of acute migraine attacks: results from a phase II study. Cephalalgia. 2011 Apr;31(5):573-84.
10	Safety and tolerability of LBR-101, a humanized monoclonal antibody that blocks the binding of CGRP to its receptor: Results of the Phase 1 program. Cephalalgia. 2013 Dec 23;34(7):483-492.