Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFTM8X)

Drug Name
PMID28870136-Compound-68 Drug Info
Cross-matching ID
TTD Drug ID
DMFTM8X

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Ecto-5'-nucleotidase (CD73)
Drug Name Drug ID Indication ICD 11 Highest Status REF
TJ004309 DMFB54Y Ovarian cancer 2C73 Phase 2 [2]
GS-1423 DMS25DL Solid tumour/cancer 2A00-2F9Z Phase 1 [3]
Oleclumab DMLVNWO Solid tumour/cancer 2A00-2F9Z Phase 1 [4]
AB680 DMGONUE Pancreatic cancer 2C10 Phase 1 [5]
TJ4309 DMM3U2Q Solid tumour/cancer 2A00-2F9Z Phase 1 [6]
CPI-006 DMJSFTX Advanced cancer 2A00-2F9Z Phase 1 [7]
LY3475070 DMZLIWX Solid tumour/cancer 2A00-2F9Z Phase 1 [8]
NZV930 DMWN2FP Solid tumour/cancer 2A00-2F9Z Phase 1 [9]
PMID28870136-Compound-57 DME3HLC N. A. N. A. Patented [1]
PMID28870136-Compound-46 DM4FD7C N. A. N. A. Patented [1]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Ecto-5'-nucleotidase (CD73) TTK0O6Y 5NTD_HUMAN Inhibitor [1]

References

1 Ectonucleotidase inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2017 Dec;27(12):1291-1304.
2 ClinicalTrials.gov (NCT05001347) A Phase 2 Clinical Study of TJ004309 in Combination With Atezolizumab (TECENTRIQ?) in Patients With Advanced or Metastatic Ovarian Cancers and Selected Advanced Solid Tumors. U.S.National Institutes of Health.
3 Clinical pipeline report, company report or official report of Agenus.
4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5 Discovery of AB680: A Potent and Selective Inhibitor of CD73. J Med Chem. 2020 Oct 22;63(20):11448-11468.
6 ClinicalTrials.gov (NCT04322006) A Phase I/II Study of TJ004309 for Advanced Solid Tumor. U.S. National Institutes of Health.
7 Clinical pipeline report, company report or official report of Corvus Pharmaceuticals.
8 CD73's Potential as an Immunotherapy Target in Gastrointestinal Cancers. Front Immunol. 2020 Apr 15;11:508.
9 Clinical pipeline report, company report or official report of Surface oncology.