General Information of Drug (ID: DMG3FDE)

Drug Name
KL044 Drug Info
Synonyms KL 044; KL-044
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
91827381
TTD Drug ID
DMG3FDE

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Preclinical Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
2-Ethoxypropanoic acid DMAM4FE Breast cancer 2C60-2C65 Preclinical [2]
KL001 DMHX1LA Glioblastoma of brain 2A00.00 Preclinical [3]
SHP656 DM8DYJQ Glioblastoma of brain 2A00.00 Preclinical [4]
TH301 DM4BDGW Glioblastoma of brain 2A00.00 Preclinical [4]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cryptochrome circadian clock 1 (CRY1) TT5MLZR CRY1_HUMAN Modulator [1]

References

1 Development of Small-Molecule Cryptochrome Stabilizer Derivatives as Modulators of the Circadian Clock. ChemMedChem. 2015 Sep;10(9):1489-97.
2 The cryptochrome inhibitor KS15 enhances E-box-mediated transcription by disrupting the feedback action of a circadian transcription-repressor complex. Life Sci. 2018 May 1;200:49-55.
3 Identification of small molecule activators of cryptochrome. Science. 2012 Aug 31;337(6098):1094-7.
4 Circadian rhythm as a therapeutic target. Nat Rev Drug Discov. 2021 Apr;20(4):287-307.